Table 5.

Adverse events

	Monotherapy etanercept	Patients, n	Combination therapy etanercept with fumarates	Patients, n
Minor adverse events
Gastrointestinal complaints	1	1	38	11
Flushing	1	1	4	4
Elevation of liver enzymes			1	1
Influenza-like symptoms	9	7	14	10
Headache			1	1
Fatigue	2	1	1	1
Pruritus	2	1	2	2
Injection site reactions	1	1	1	1
Operation	1 (tonsillectomy)	1	1 (meniscus surgery)	1
Other	1 (minor trauma)	1	2 (1 bacterial infection + 1 bladder infection)	2
Major adverse events
Serious adverse event	1 iron deficiency anaemia	1
Severe adverse event	1 (admission to the hospital)	1	2 (admission to the hospital)	1