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. 1991 Dec 1;88(23):10740–10743. doi: 10.1073/pnas.88.23.10740

Inhibition of the activation of Hageman factor (factor XII) by human vascular endothelial cell culture supernates.

O D Ratnoff 1, B Everson 1, P Embury 1, N P Ziats 1, J M Anderson 1, M M Emanuelson 1, C J Malemud 1
PMCID: PMC53006  PMID: 1961740

Abstract

The supernatant fluid (conditioned medium) of cultured human vascular endothelial cells inhibits activation of Hageman factor (factor XII), whether by ellagic acid, bovine brain sulfatides, or bismuth subgallate; inhibition appears to be a property of one or more proteins in the culture supernates. This phenomenon may contribute to maintaining the fluidity of circulating blood by inhibiting surface activation of the intrinsic pathway of coagulation.

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Selected References

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