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. Author manuscript; available in PMC: 2017 Jul 1.
Published in final edited form as: Small. 2016 May 27;12(26):3559–3567. doi: 10.1002/smll.201600673

Figure 5.

Figure 5

Increased co-localization of chitosan-coated fMNPs with lysosomes and reduced intracellular trafficking might contribute to age-dependent neuro-protective effects of chitosan-coatings on fMNPs. (A) Chitosan-coatings increased dendritic spine density in immature (6-day-old) neurons but decreased dendritic spine density in mature (30-day-old) neurons. (B) There was greater net retention of NPs and (C) co-localization of NPs with lysosomes in older neurons (either induced by CCL11 treatment or natural aging). (D) The root mean square velocity of NPs (both retrograde (* p < 0.05) and anterograde (# p < 0.05) transport) in older neurons was significantly less than that in younger neurons.