Multiple cavitating pulmonary nodules: rare manifestation of benign metastatic leiomyoma

Abstract

Benign metastasizing leiomyoma (BML) is a rare disease of pathologically benign, but the tumor metastasizes to other organs. The most common organ involved in BML is lung. Pulmonary involvement usually manifested as multiple nodules on chest X-ray, however we experienced an interesting case of a 52-year-old premenopausal woman who presented with multiple bilateral lung cavitations and nodules on a chest X-ray without any respiratory symptoms. Chest computed-tomography identified multiple cavitary lesions of 5–12 mm in diameter and well-defined nodules of 5–10 mm in diameter in both lung fields. Transthoracic needle biopsy was performed and the resected lesion consisted of benign spindle cells was positive for estrogen receptor (ER) and progesterone receptor (PR) and was diffuse positive for actin and desmin by immunohistochemical (IHC) staining, suggesting leiomyoma. The final diagnosis was benign pulmonary metastasizing leiomyoma (BPML) and the patient underwent subcutaneous injection of a gonadotrophin releasing hormone (GnRH) agonist for 12 months, follow-up low-dose chest computed tomography (CT) scan at 15 months revealed decreased cavitations and nodular lesions. We should take into consideration the possibility of BPML when we encounter multiple cystic or cavitary lesions on chest X-ray, although the common form of BPML is nodulary lesions on imaging studies.

Case presentation

A 52-year-old premenopausal woman presented with multiple bilateral lung cavitations and nodules on a chest X-ray performed for health screening. The patient was a non-smoker, and her general condition was good. The patient had undergone laparoscopically-assisted vaginal hysterectomy 10 years prior to this presentation for leiomyoma of the uterus. The myoma was multiple, intramural type with pathologically proven benign leiomyoma. She had not previously suffered from any pulmonary disease, such as pulmonary tuberculosis or pneumonia. The patient did not exhibit any of the symptoms of pulmonary disease, such as coughing, dyspnea, or chest pain. Her breath sound was clear, and no rales were noted. Because her chest X-ray was abnormal, a chest computed tomography (CT) was performed. Her CT identified multiple cavitary lesions of 5–12 mm in diameter and well-defined nodules of 5–10 mm in diameter in both lung fields (Figure 1). Abdominal-pelvic CT, esophago-gastro-duodenoscopy (EGD), and positron emission tomography (PET)-CT were performed to determine whether the lesions were primary or metastatic neoplasms; however, there were no signs that the lesions were malignant (Figures 2,3). The results of the oxygen saturation test and blood chemistry tests, including carcinoembryonic antigen (CEA) and carbohydrate antigen 125 (CA-125) measurements, were all within the normal limits. However, the patient’s neuron-specific enolase (NSE) level was slightly increased to 24.4 ng/mL (normal range, 0–16.4 ng/mL). Transthoracic needle biopsy was performed on a 10 mm nodule located in the right lower lobe. The pathologic examination revealed a spindle cell bundle, and the mass was positive for estrogen receptor (ER) and progesterone receptor (PR) by immunohistochemical (IHC) staining. The mass was positive for actin and desmin suggesting leiomyoma (Figure 4). Neither mitosis nor atypia were noted, and the immunohistochemistry results for markers of pulmonary carcinoma, including thyroid transcription factor-1 (TTF-1) and pan-cytokeratin, were also negative. Based on the physical examination, imaging studies and pathologic diagnosis of the lung nodule, the final diagnosis was benign metastasizing leiomyoma (BML). The patient underwent subcutaneous injection of a gonadotrophin releasing hormone (GnRH) agonist for 12 months, and her bone mineral density was monitored from 6 months and throughout the treatment. Follow-up low-dose chest CT scan at 15 months revealed decreased cavitations and nodular lesions (Figure 5). The patient tolerated the treatment and had no symptoms throughout 30 months of follow-up. Written informed consent was obtained from the patient for publication of this case report and any accompanying images.

Figure 1.

Simple chest roentgenography at presentation. (A) Simple chest roentgenography (X-ray) shows multiple small nodules in both lungs; (B) simple chest X-ray shows performed 18 months after diagnosis of benign pulmonary metastasizing leiomyoma (BPML) shows decreased size of multiple small nodules in both lungs.

Figure 2.

Chest computed tomography (CT) at presentation. (A) Right lung on transverse thin section CT scan (1.0 mm collimation) obtained with lung window at the level of innominate vein shows a small thin walled cystic nodule (arrow) with well-defined solid nodule in in right upper lobe (arrowhead); (B) right lung on transverse thin section CT scan (1.0 mm collimation) obtained with lung window at the level of basal lobes demonstrates well demarcated several solid nodules with predominance of subpleural locations.

Figure 3.

Positron emission tomography (PET) maximum intensity projection (MIP) image shows no significant FDG-avid foci in thorax.

Figure 4.

Pathologic findings of the pulmonary mass. (A) Muscle cells arranged in various directions in hematoxylin and eosin (H & E) stain (×200); (B) immunohistochemical (IHC) staining for estrogen receptor (ER) and progesterone receptor(PR) showed both positive staining (×200); (C) IHC staining for anti-smooth-muscle-actin showed positive staining (×200).

Figure 5.

Low-dose chest computed tomography (CT) scan at 15 months after treatment. (A) Right lung on coronal section CT scans (3.0 mm collimation) obtained with lung window shows a small thin walled cystic nodule in right upper lobe (arrows) with well-defined solid nodules (arrowheads); (B) left lung on coronal section CT scans (3.0 mm collimation) obtained with lung window shows well defined solid nodules (arrowheads).

Discussion

First reported in 1939 by Steiner (1), BML is a rare disease. It is a rare tumor composed of proliferative smooth muscle cells that are pathologically benign, but the tumor is characteristically malignant from the clinical perspective, as it metastasizes to other organs. BML particularly affects women with a history of surgical management on uterine myoma, such as hysterectomy or myomectomy (2-4). In most cases, it affects the lungs (2-8), but other reported sites include the lymph nodes, heart, skull, inferior venae cava, backbone, retroperitoneum and bones (9). The tumor is considered metastatic because it forms multiple remote metastatic lesions, but it is benign pathologically because it has a low mitotic index, lacks diverse nuclei, and does not infiltrate into the surrounding tissues (2). However, the tumor exhibits clinically malignant characteristics, as it originally arises from the uterus and metastasizes to other organs, which accounts for the ironic terminology of BML (2,10,11).

BML is a rare condition and commonly found in women of 35–55 years of age, 3 to 20 years (median: 14.9 years) after the patient underwent hysterectomy or uterine myomectomy (10,12). It typically occurs in reproductive-aged women, but some cases have been reported in pregnant and postmenopausal women. Most cases are asymptomatic and are accompanied by a pelvic mass (13,14), but in some cases, BML is identified because of respiratory or gastro-intestinal symptoms, including chest stiffness, massive hemoptysis or intestinal obstruction (8,15,16). Three hypotheses have been proposed to explain the pathogenesis of BML: the first is that BML is a malignant uterine sarcoma that had gone underdiagnosed pathologically as benign uterine myoma and had subsequently metastasized to the lung. The second is that it is a benign uterine myoma that embolized mechanically during surgical instrumentation to the lung, and the third is that it is a lesion caused by increased growth of smooth muscle cells in various organs, such as the uterus or lungs, due to an abnormally elevated level of estrogen (17). Tietze et al. performed analyses of leiomyoma of the uterus, metastasizing leiomyoma of the lung and disseminated abdominal leiomyomatosis and commonly found an increased number of smooth muscle cells originating from a single cell and inactivation of the same X chromosome in those cells; this generates a higher probability of metastatic pathogenesis than multiple pathogenesis for BML (13). At present, benign pulmonary metastasizing leiomyoma (BPML) is generally classified as a type of leiomyomatosis that mostly involves the uterus and lungs. To obtain a diagnosis of BPML, it is essential to exclude pathologically malignant uterine sarcoma that metastasized to the lung and we should not overlook evidence of sarcoma by re-examining numerous tissue samples of the prior primary leiomyoma of the uterus. In comparison of ten cases of BPML with two cases of uterine sarcoma that metastasized to the lung, the BPML commonly occurred in premenopausal women and rarely invaded both lungs, with lung lesions being found at a median of 14.9 years after hysterectomy (12). In contrast, uterine sarcoma commonly metastasized to the lung in menopausal women and typically invaded both lungs, with lung lesions being found much sooner after hysterectomy than for BPML at a median of 4.5 years after hysterectomy (15). Generally, features that indicate benign lesions rather than malignant lesions include cell death, dysplastic karyotype and various histological morphologies, among which cell division activity is considered the most important (15). When compared to sarcoma, BPML has lower mitotic activity, higher expression rates of ER and PR, and lower angiogenesis (13).

BPML patients display diverse symptoms: often, BPML is revealed incidentally without symptoms, but occasionally mild fever, dry cough, and sputum are observed as early signs. Rarely, patients suffering from BPML come to the clinic as first-time visitors for the evaluation of dyspnea due to heart invasion or respiratory failure due to obstruction of the trachea caused by a large cystic myoma formed in the lung (14-16). The typical radiological finding of BPML is well-circumscribed pulmonary nodules with multiple boundaries; rarely reported radiological findings include a miliary pattern (18), cavitary lung nodules (19,20), interstitial lung disease and multiloculated fluid-containing cystic lesions (6). In summary this atypical presentation of cavitating pulmonary nodules provides interesting diagnostic challenge. Therefore we should take into consideration this rare disease entity of BPML with diverse radiologic findings of lung, multiple cavitations as in this case especially in women who had undergone myomectomy or hysterectomy for uterine leiomyoma.

Informed Consent: Written informed consent was obtained from the patient for publication of this manuscript and any accompanying images.