Figure 1. Pedigree and clinical features of the studied autosomal recessive Charcot-Marie-Tooth 2 family.

(A) Family tree. Square symbols represent males and circles females. Black symbols indicate affected individuals. (B) Serial images of the patients. Patient II-1 at age 32 presents with unilateral mild hypotrophy and weakness of the muscles in the first interosseal space, bilateral atrophy, and severe weakness (Medical Research Council scale 0–2) of all distal leg muscles. Patient II-2 at age 28 has normal appearance of the distal muscles of the hands, unilateral severe weakness of hallux extensor, and normal standing on tiptoe.