Table 3. Haplotype association in 5 significant SNPs, adjusted by smoking duration^a,b.

Hap	rs1970764	rs967591	rs100761	rs62109563	rs3212965	Control frequency	Case frequency	OR (95% CI)	P-value
1	A	G	C	T	T	0.2731	0.2473	1.00	---
2	G	A	C	C	C	0.217	0.2615	1.44 (1.05 - 1.97)c	0.022c
3	G	G	T	T	C	0.1198	0.1262	1.12 (0.76 - 1.66)	0.57
4	A	G	T	T	C	0.1123	0.0876	0.85 (0.54 - 1.33)	0.47
5	A	A	C	C	C	0.0879	0.0995	1.33 (0.82 - 2.15)	0.25
6	G	G	C	T	T	0.0336	0.0509	1.80 (0.92 - 3.54)	0.088
7	A	A	C	T	C	0.0365	0.0449	1.32 (0.68 - 2.55)	0.41
8	G	A	C	T	C	0.0365	0.0339	1.12 (0.56 - 2.25)	0.75

^aAnalyzed by SNPStats program. Haplotypes with frequency < 0.03 in both cases and controls were excluded

^bGlobal haplotype association P-value = 0.023

^cBoldface means association with increased susceptibility of lung cancer