Table 8. Polymorphisms and methods of analysis.
| Main Gene Function | Gene Name_Polymorphism | Reference SNP Number | Method of Analysis | Reference |
|---|---|---|---|---|
| Transport | ABCB1_3435T/C | rs1045642 | PSQ | [28] |
| ABCB1_1236T/C | rs1128503 | PSQ | [28] | |
| ABCB1_2677G > T/A | rs2032582 | PSQ | ||
| ABCC2_1249A/G | rs2273697 | PSQ | [28] | |
| ABCC2_-24A/G | rs717620 | PSQ | [28] | |
| ABCC2_3972A/G | rs3740066 | taqman assay | ||
| ABCG2_34A/G | rs2231137 | taqman assay | ||
| ABCG2_421A/C | rs2231142 | taqman assay | ||
| RFC_80A/G | rs1051266 | PSQ | ||
| DNA Repair | APE1_2197T/G | rs1130409 | taqman assay | |
| ERCC1_8092T/G | rs3212986 | taqman assay | [29] | |
| ERCC1_19007T/C | rs11615 | taqman assay | [29] | |
| hMLH1_676A/G | rs1799977 | PSQ | [28] | |
| hMSH2_IVS12-6T/C | rs2303428 | PSQ | [28] | |
| hOGG1_1245C/G | rs1052133 | taqman assay | [28] | |
| XPD_35931T/G | rs13181 | PSQ | [29] | |
| XPD_23591A/G | rs1799793 | PSQ | [29] | |
| XPG_3508G/C | rs17655 | PSQ | [29] | |
| XRCC1_28152A/G | rs25487 | taqman assay | [28] | |
| XRCC3_18067T/C | rs861539 | PSQ | [28] | |
| Folate cycle | DHFR_Ins/Del | rs70991108 | PCR | |
| FOLR1_181delC | rs3833748 | RFLP/PSQ | ||
| GGH_452T/C | rs11545078 | taqman assay | ||
| GGH_401T/C | rs3758149 | taqman assay | ||
| GGH_16T/C | rs1800909 | taqman assay | ||
| MTHFD1_1958T/C | rs2236225 | taqman assay | ||
| MTHFR_677T/C | rs1801133 | PSQ | ||
| MTHFR_1298A/C | rs1801131 | PSQ | ||
| SHMT_1420T/C | rs2273029 | taqman assay | ||
| TYMS_28bp_VNTR | rs34743033 | PCR/RFLP | [30] | |
| TYMS_1494del6 | rs16430 | PCR/RFLP | [30] | |
| Apoptosis | ATM_40C/G | rs1800054 | taqman assay | |
| ATM_61A/G | rs1801516 | taqman assay | ||
| MDM2_309T/G | rs2279744 | PSQ | [14] | |
| p21_98A/C | rs1801270 | taqman assay | ||
| TP53_PIN3_IVS3 + 16 bp | rs17878362 | PCR | ||
| TP53_IVS2+38G/C | rs1642785 | taqman assay | ||
| TP53_ex4+119G/C | rs1042522 | PSQ/taqman assay | [14] | |
| Drug metabolism | GSTT1_gen_null | rs_GSTT1_gen_null | PCR | [28] |
| GSTM1_gen_null | rs_GSTM1_gen_null | PCR | [28] | |
| GSTP1_313A/G | rs1695 | PSQ | ||
| CYP2C19*2_681A/G | rs4244285 | PSQ | ||
| CYP2B6*6(516T/G + 785A/G) | rs3745274 and rs2279343 | RFLP | ||
| CYP2B6*7(*6 + 1459T/C) | rs3745274 and rs2279343 and rs3211371 | RFLP | ||
| CYP2C9*2_430T/C | rs1799853 | PSQ | ||
| CYP2C9*3_1075A/C | rs1057910 | PSQ | ||
| CYP3A4*1B_-392A/G | rs2740574 | PSQ |
PSQ: pyrosequencing, PCR: polymerase chain reaction, RFLP: restriction fragment length polymorphism.