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The Journal of Clinical Hypertension logoLink to The Journal of Clinical Hypertension
. 2016 Nov 14;19(2):116–125. doi: 10.1111/jch.12942

Baseline blood pressure control in Hispanics: characteristics of Hispanics in the Systolic Blood Pressure Intervention Trial

Carlos J Rodriguez 1,2,, Carolyn H Still 3, Katelyn R Garcia 4, Lynne Wagenknecht 1, Suzanne White 5, Jeffrey T Bates 6, Margareth V Del Cid 7, Michael Lioudis 8, Nieves Lopez Barrera 9, Abel Moreyra 10, Henry Punzi 11, Robert J Ringer 12, William C Cushman 13, Gabriel Contreras 14, Karen Servilla 15, Michael Rocco 1,16; the SPRINT Research Group
PMCID: PMC5309142  NIHMSID: NIHMS818978  PMID: 27862904

Abstract

The Systolic Blood Pressure Intervention Trial (SPRINT) tested whether a systolic blood pressure (SBP) value <120 mm Hg reduces adverse clinical outcomes compared with the goal of <140 mm Hg. Here the authors describe the baseline characteristics of Hispanic participants in SPRINT. Nondiabetic hypertensive patients 50 years and older with SBP 130–180 mm Hg taking zero to four blood pressure (BP) medications were enrolled from the mainland United States and Puerto Rico. Cross‐sectional, bivariate analysis was employed comparing sociodemographic and clinical factors in Hispanics vs non‐Hispanics. Multivariable logistic regression models restricted to Hispanics were used to identify factors associated with achieved BP control (SBP <140 mm Hg and diastolic BP <90 mm Hg) at baseline. Eleven percent (n=984) of SPRINT participants were Hispanic; 56% (n=549) of Hispanics were living in Puerto Rico and the remainder were living on the US mainland. Hispanics overall were younger, more often female, less likely to live alone, and more likely to have lower education and be uninsured, although just as likely to be employed compared with non‐Hispanics. BP control was not different between Hispanics vs non‐Hispanics at baseline. However, a significantly higher percentage of Hispanics on the US mainland (compared with Hispanics in Puerto Rico) had controlled BP. BP control was independently associated with cardiovascular disease history and functional status among Hispanics, specifically those living in Puerto Rico, whereas functional status was the only independent predictor of BP control identified among mainland Hispanics. These findings highlight the diversity of the SPRINT population. It remains to be seen whether factors identified among Hispanics impact intervention goals and subsequent clinical outcomes.

Keywords: blood pressure, clinical trials, Hispanics

1. Introduction

Hypertension (elevated blood pressure [BP]) is a global public health concern and affects billions of individuals worldwide. In the United States, the prevalence of hypertension in the adult population is 29.1% and is estimated to affect 71 million persons.1 Although hypertension‐related mortality rates have increased among Hispanics,2, 3 there is a remarkable lack of consistent information regarding hypertension among US Hispanics. The prevalence of hypertension among Mexicans (28.7% in men, 31.4% in women) is not elevated compared with the general population2; however, longitudinal data show that it is on the rise. The age‐adjusted prevalence of hypertension among Mexican Americans increased from 17.2% in 1988–1991 to 20.7% in 1999–2000 and to 27.8% in 2003–2004.4, 5 This is a disturbing trend. Furthermore, Hispanics are more likely to have undiagnosed, untreated, or uncontrolled hypertension than other ethnic groups.6, 7, 8

Differences by Hispanic subgroup are evident. Compared with Caucasians, adjusted odds of self‐reported hypertension were 67% higher among Dominicans; 20%–27% lower among Mexicans and Central/South Americans.9 Among Northern Manhattan Study (NOMAS) participants (predominantly Hispanics of Dominican background), the prevalence of hypertension was similarly high among Hispanics (59%) compared with non‐Hispanic blacks (64%).10 Similar results have been found in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL) where the prevalence of hypertension among Hispanic men was the highest (32.6%) among Dominicans and lowest among South American men (19.9%).11

During the past decade, numerous large‐scale clinical trials have demonstrated that lowering BP, using various antihypertensive agents, will reduce the risk of cardiovascular morbidity and mortality. However, such findings may not be entirely applicable to racial/ethnic groups, including Hispanics/Latinos, as they are underrepresented and understudied in such clinical trials, which may explain the continued disparities observed in hypertension and its related outcomes. It is warranted that clinical trials include diverse samples and examine the efficacy of antihypertensive therapies and their ability to achieve BP control and lower the risk of cardiovascular morbidity and mortality.

The Systolic Blood Pressure Intervention Trial (SPRINT) is a multicenter, randomized clinical trial designed to test whether treating systolic BP (SBP) to a lower goal than currently recommended <140 mm Hg will reduce cardiovascular disease (CVD) risk among nondiabetic hypertensive patients older than 50 years. SPRINT was successful in recruiting an ethnically diverse population, including Hispanic/Latinos. The aim of this manuscript is to evaluate baseline characteristics and factors associated with baseline BP control (SBP <140 mm Hg and diastolic BP [DBP] <90 mm Hg) in Hispanics/Latinos in SPRINT.

2. Methods

The design and rationale of SPRINT have previously been reported.12 Briefly, SPRINT is a two‐armed, multicenter, randomized, open‐label, clinical trial designed to test whether a strategy to treat SBP to <120 mm Hg will reduce CVD outcomes among nondiabetic hypertensive participants compared with treating to the currently recommended SBP target of <140 mm Hg. In addition, the SPRINT Memory and Cognition In Decreased Hypertension (SPRINT MIND) substudy will test whether the lower SBP goal influences the rate of incident dementia and mild cognitive impairment, global and domain‐specific cognitive function, and cerebral small vessel ischemic disease.

Participants include men and women 50 years and older with SBP between 130 mm Hg and 180 mm Hg taking zero to four antihypertensive medications with at least one additional CVD risk factor. The SPRINT recruitment target was 9250, including additional targets of enrolling 50% women and 40% minorities. Self‐reported race and ethnicity was collected separately from all participants. Of those who classified themselves as Hispanic, they were asked whether they considered their ancestry to be of Puerto Rican, Cuban, Mexican, or other Hispanic background. The protocol was designed to enroll three high‐risk subgroups: participants with chronic kidney disease (CKD; estimated glomerular filtration rate [eGFR] 20–59 mL/min/1.73 m2), those with clinical CVD (myocardial infarction, coronary revascularization, carotid endarterectomy/stenting, and/or peripheral artery disease with revascularization) or subclinical CVD (left ventricular hypertrophy; ≥50% stenosis of a coronary, carotid, or lower extremity artery; abdominal aortic aneurysm >5 cm with or without repair; ankle brachial index ≤0.90; and/or coronary artery calcium score ≥400 Agatston units), and seniors who were at least 75 years of age. Patients with a Framingham Risk Score >15, age 75 years or older, and/or CKD who met the BP eligibility criteria were automatically eligible for enrollment. Individuals with diabetes, proteinuria ≥1 g/d, history of stroke, eGFR <20 mL/min/1.73 m2, and heart failure were excluded. Participants were recruited from 102 clinical sites across the US and Puerto Rico (PR) between November 2010 and March 2013. The clinics were organized into five regional Clinic Center Networks detailed on the SPRINT Web site with contact information and a map of all participating clinics.13 All clinics obtained institutional review board approval and each participant provided written informed consent.

2.1. Baseline visits and procedures

BP measurements (sitting and standing) were collected using a standard automated BP device. The average of three seated BPs and pulse readings were measured after sitting quietly for 5 minutes, with the patients’ backs supported and feet flat on the floor. A single standing BP and pulse measurement was obtained, followed by questioning the participant for symptoms of orthostatic hypotension.

Anthropometric measurements (height and weight), fasting blood and urine samples, and a 12‐lead electrocardiogram were performed. All participants completed dementia screening (eg, Montreal Cognitive Assessment [MoCA], Logical Memory (LM)—Immediate and Delayed Recall, and Digit Symbol Coding [DSC]). The MoCA was designed as a rapid screening instrument of global cognitive function. The LM tests measure episodic verbal memory. Participants read a short story that consisted of specific bits of information and recall was tested. The DSC assesses sustained attention, concentration, visuomotor coordination, and processing speed. A Spanish‐translated version of the SPRINT cognitive battery was provided by the SPRINT coordinating center for Spanish‐speaking participants (mainland as well as PR Hispanics) for use at the participant's request. In addition, participants completed several self‐administered questionnaires assessing general health‐related quality of life (HRQOL) measures and its three subscales: (1) general physical and mental health status (Veterans RAND 12 [VR‐12]), the VR‐12 is a shorter version of the 36‐Item Short Form health survey, a reliable, established, and valid HRQOL measure.14 Scores on the VR‐12 range from 0 to 100, with higher scores suggesting more favorable HRQOL. (2) Health utility such as mobility, self‐care, usual activities, pain/discomfort (EuroQol‐5D [EQ‐5D]); the EQ‐5D15 includes a single summary index with higher scores denoting self‐perceived greater mobility, increased ability for self‐care, and lower pain. (3) Depressive symptoms (Patient Health Questionnaire‐9 [PHQ‐9]); the PHQ‐916 is a self‐report measure of depressive symptoms over the previous 2 weeks. Possible scores range from 0 to 27, with higher scores suggesting more depressive symptoms. The Functional Activities Questionnaire (FAQ) is a 10‐item, validated questionnaire,17 administered to assess daily functional status during the past 4 weeks. Items assess common daily functions such as managing money and remembering names of familiar persons. Additional questionnaires queried participants about their sociodemographics, medical history, general health and quality of life, smoking/alcohol use, and concomitant medications. Antihypertensive medication adherence was assessed using the self‐administered Morisky Medication Adherence Scale where lower numerical scores equate to lower adherence. Participation in physical activity was defined as engaging in vigorous activity two or more times per week or spending ≥30 minutes per day in a less vigorous activity ascertained using a previously validated set of questions.18 Race and ethnicity was based on a series of interview questions modeled on the 2000 US Census. Ethnicity was subdivided as Hispanic or non‐Hispanic based on the question: “Is the participant of Hispanic or Latino origin?” All participants who self‐identified as Hispanic/Latino were categorized as Hispanic. Clinical laboratory measurements were performed at the study's central laboratory to ensure uniformity of test methods and procedures for all samples. eGFRs were calculated using the Modification of Diet in Renal Disease equation.19

2.2. Statistical analysis

Baseline measurements prior to randomization to the SBP treatment targets were analyzed in this report. Descriptive statistics were computed overall, by Hispanic ethnicity (Hispanics and non‐Hispanics) and for Hispanics by geographic location (US mainland and PR). Means and standard errors were obtained for continuous measures, and frequencies and percentages for categorical factors. Differences between groups were assessed using two‐sample t tests (with Satterthwaite adjustment for unequal variances when necessary) for continuous factors, and chi‐square tests for categorical factors. BP treatment for all participants and for participants with SBP ≥160 mm Hg was assessed using means and standard errors to determine the number of medications used in participants and frequencies; and percentages to assess the number of participants taking each class of antihypertensive medication. Differences between groups were assessed using two‐sample t tests (with Satterthwaite adjustment for unequal variances when necessary) for continuous factors, and chi‐square tests or Fisher exact tests for categorical variables depending on the adequacy of the sample size. Univariable logistic regression analysis was used to examine sociodemographic, clinical, and study measures to determine which variables were independently associated with BP control (defined as <140/90 mm Hg) in Hispanics at baseline. Variables with a P<.10 in univariable logistic regression models were selected for our multivariable logistic regression models. Models were fit separately for all Hispanics, Hispanics living in PR, and Hispanics living on the US mainland. Statistical significance was assessed at the two‐sided 0.05 alpha level; no adjustments for multiple testing were completed. All analyses were performed using SAS version 9.4 (SAS Institute Inc., Cary, NC, USA).

3. Results

3.1. Baseline and clinical characteristics

Of the 9361 participants enrolled in SPRINT, 11% (n=984) are Hispanics. Compared with non‐Hispanics, Hispanics were younger, more likely to be female, less likely to live alone, and more likely to have a lower than high school education but as likely to be employed. Hispanics were more likely to be uninsured or covered by Medicaid. Overall in SPRINT, 9.4% of participants were taking no BP medications at baseline, with a significantly lower proportion of Hispanics being untreated compared with non‐Hispanics. However, mean SBP was higher among Hispanics compared with non‐Hispanics, while the average number of prescribed antihypertensive medications was lower. Prevalence of clinical CVD history was similar among Hispanics and non‐Hispanics; however, Hispanics had a lower average number of chronic diseases. Hispanics were less likely to engage in physical activity or be a current or past smoker. Hispanics had higher total cholesterol, higher low‐density lipoprotein (LDL), lower high‐density lipoprotein (HDL), and higher triglycerides than non‐Hispanics, with considerably higher eGFR and lower creatinine values (Tables 1 and 2).

Table 1.

Sociodemographics of Systolic Blood Pressure Intervention Trial participants stratified by race‐ethnicity and region

Overall (N=9361) Hispanics (n=984) Non‐Hispanics (n=8377) P Value Hispanics living in Puerto Rico (n=549) Hispanics living in US Mainland (n=435) P Value
Age, y . . . <.0001 . . .00021
<65 3805 (40.65) 508 (51.63) 3297 (39.36) 294 (53.55) 214 (49.2)
65–74 2904 (31.02) 298 (30.28) 2606 (31.11) 180 (32.79) 118 (27.13)
>75 2652 (28.33) 178 (18.09) 2474 (29.53) 75 (13.66) 103 (23.68)
Sex . . . <.0001 . . <.0001
Male 6029 (64.41) 530 (53.86) 5499 (65.64) 251 (45.72) 279 (64.14)
Female 3332 (35.59) 454 (46.14) 2878 (34.36) 298 (54.28) 156 (35.86)
Living status . . . .00025 . . .07853
Lives with other(s) 6627 (70.95) 746 (75.97) 5881 (70.36) 428 (78.1) 318 (73.27)
Lives alone 2714 (29.05) 236 (24.03) 2478 (29.64) 120 (21.9) 116 (26.73)
Marital status . . . .72208 . . .32639
Married 1613 (54.05) 146 (55.09) 1467 (53.95) 80 (57.97) 66 (51.97)
Not married 1371 (45.95) 119 (44.91) 1252 (46.05) 58 (42.03) 61 (48.03)
Education . . . <.0001 . . <.0001
<High school 876 (9.38) 231 (23.52) 645 (7.71) 106 (19.34) 125 (28.8)
High school 4214 (45.1) 350 (35.64) 3864 (46.21) 170 (31.02) 180 (41.47)
Associates degree 619 (6.62) 65 (6.62) 554 (6.63) 45 (8.21) 20 (4.61)
College degree 2089 (22.36) 208 (21.18) 1881 (22.49) 136 (24.82) 72 (16.59)
Graduate degree 1033 (11.06) 97 (9.88) 936 (11.19) 71 (12.96) 26 (5.99)
Postgraduate 513 (5.49) 31 (3.16) 482 (5.76) 20 (3.65) 11 (2.53)
Employment . . . .55748 . . .07842
Employed 3213 (34.39) 346 (35.23) 2867 (34.29) 180 (32.85) 166 (38.25)
Unemployed (includes retirees) 6129 (65.61) 636 (64.77) 5493 (65.71) 368 (67.15) 268 (61.75)
Health insurance . . . .01698 . . <.0001
Insured 8360 (89.57) 858 (87.37) 7502 (89.83) 514 (93.8) 344 (79.26)
Uninsured 973 (10.43) 124 (12.63) 849 (10.17) 34 (6.2) 90 (20.74)
Primary care provider 8965 (96.11) 935 (95.21) 8030 (96.21) .12538 520 (94.89) 415 (95.62) .59379

US mainland refers to the 50 states (including Alaska and Hawaii) and the District of Columbia.

Table 2.

Baseline clinical characteristics of Systolic Blood Pressure Intervention Trial participants stratified by race‐ethnicity and region

Hispanics (n=984) Non‐Hispanics (n=8377) P Value for Hispanic difference overall Hispanics living in Puerto Rico (n=549) Hispanics living in US Mainland (n=435) P Value for Island vs Mainland difference overall
Baseline BP . .
SBP, mm Hg 140.68±0.47 139.55±0.17 .02397 142.97±0.6 137.78±0.72 <.0001
DBP, mm Hg 77.46±0.36 78.21±0.13 .0487 78.31±0.47 76.38±0.54 .00737
BP controlled 485 (49.39) 4212 (50.38) .55812 241 (43.98) 244 (56.22) .00014
Pulse 65.77±0.34 66.31±0.13 .13142 65.72±0.41 65.84±0.56 .8654
No. of BP medications 1.75±0.03 1.84±0.01 .00341 1.69±0.04 1.83±0.05 .02136
Not taking antihypertensive agents 75 (7.62) 807 (9.63) .04102 37 (6.74) 38 (8.74) .24123
Weight, lb 177.89±1.14 192.04±0.46 <.0001 177.95±1.55 177.83±1.69 .95806
BMI, kg/m2 29.54±0.17 29.89±0.06 .04994 29.75±0.23 29.27±0.23 .1483
Physical activity 397 (40.47) 3879 (46.56) .0003 219 (39.96) 178 (41.11) .71674
CVD history 184 (18.7) 1693 (20.21) .2628 84 (15.3) 100 (22.99) .00213
Smoking status . . <.0001 <.0001
Current 113 (11.52) 1127 (13.49) 60 (10.95) 53 (12.24)
Past 303 (30.89) 3670 (43.93) 135 (24.64) 168 (38.8)
No. of chronic diseases 2.2±0.05 2.73±0.02 <.0001 2.03±0.06 2.43±0.08 <.0001
Baseline values . .
Fasting glucose, mg/dL 98.42±0.38 98.86±0.15 .27988 98.3±0.46 98.57±0.63 .7282
Total cholesterol, mg/dL 193.85±1.29 189.68±0.45 .00269 198.2±1.7 188.33±1.94 .00014
LDL cholesterol, mg/dL 114.55±1.11 112.14±0.39 .04266 118.24±1.48 109.88±1.66 .00019
HDL cholesterol, mg/dL 50.63±0.42 53.13±0.16 <.0001 51.66±0.58 49.33±0.61 .00596
Triglycerides, mg/dL 145.1±2.69 123.69±1 <.0001 141.77±3.12 149.33±4.66 .17718
Potassium, mmol/L 4.2±0.01 4.21±0 .40844 4.17±0.02 4.23±0.02 .01933
Sodium, mmol/L 140.29±0.07 140.12±0.03 .02758 140.51±0.09 140±0.11 .00049
eGFR, mL/min/1.732 77.59±0.71 71.07±0.22 <.0001 81.59±0.86 72.47±1.15 <.0001
Creatinine, mg/dL 0.96±0.01 1.09±0 <.0001 0.88±0.01 1.06±0.02 <.0001

Abbreviations: BMI, body mass index; CVD, cardiovascular disease; eGFR, estimated glomerular filtration rate; HDL, high‐density lipoprotein; LDL, low‐density lipoprotein. Values are expressed as number (percentage) or mean±standard error.

aPhysical activity was defined as participants with two or more times of vigorous activity per week or 30 or more minutes of less vigorous activity per week.

bControlled blood pressure (BP) is defined as systolic BP (SBP) <140 mm Hg and diastolic BP (DBP) <90 mm Hg.

3.2. Baseline study measures

HRQOL measures and its three subscales VR‐12, EQ‐5D, and PHQ‐9 are shown in Table 3. The mean score for the VR‐12 was higher among Hispanics. Hispanics had a higher average score on health perception and a higher average score on depressive symptoms, meaning Hispanics had a more favorable perception of health but experienced more depressive symptoms. Satisfaction with medical care did not differ significantly among Hispanics vs non‐Hispanics. Hispanics had similar compliance to their prescribed treatment compared with non‐Hispanics. Hispanics scored significantly lower on every cognitive measure assessment compared with non‐Hispanics. The largest discrepancy was on the MoCA where Hispanics had a mean score almost three points lower than non‐Hispanics. The pattern was similar for scores on the LM test (both immediate and delayed recall) as well as the forward and backward digit span. Across age and education strata, Hispanics scored worse on cognitive measures compared with non‐Hispanics; however, the discrepancy in scores was largest among older (65 and older) and less educated (less than high school educational attainment) Hispanics. (Data not shown.)

Table 3.

Means and standard deviations of study baseline measures

Hispanics (n=984) Non‐Hispanics (n=8377) P Value for Hispanic difference overall Hispanics in Puerto Rico (n=549) US Mainland Hispanics (n=435) P Value for Island vs Mainland difference overall
Health‐related quality of life . . . .
General health status 2.81±0.89 2.63±0.84 <.0001 2.68±0.84 2.97±0.92 <.0001
EuroQol‐5D (health utility) 0.82±0.15 0.84±0.15 <.0001 0.82±0.14 0.81±0.17 .07981
Patient Health Questionnaire‐9 3.6±4.42 3.01±4.13 <.0001 3.21±3.86 4.08±4.99 .00287
Depressive symptoms 0.09±0.29 0.08±0.27 .09402 0.06±0.23 0.14±0.34 <.0001
Patient satisfaction 1.64±0.82 1.67±0.82 .19073 1.64±0.84 1.63±0.81 .85651
Dementia screening . . . .
Logical memory I (0–28) 16.71±5.3 19.42±4.79 <.0001 16.95±5.3 16.39±5.3 .10838
Logical memory II (0–14) 7.29±3.52 8.26±3.33 <.0001 7.46±3.5 7.05±3.54 .07353
Montreal Cognitive Assessment 20.93±4.89 23.12±3.94 <.0001 21.25±4.84 20.51±4.92 .02049
Digit Symbol Coding: forward 7.91±2.39 9.68±2.41 <.0001 8.07±2.39 7.78±2.39 .36598
Digit Symbol Coding: backward 6.53±2.32 7.41±2.24 <.0001 6.94±2.58 6.22±2.05 .0229
Functional assessment (Functional Activities Questionnaire) 2.65±4.14 1.39±3.09 <.0001 2.88±4.06 2.35±4.23 .18834
Morisky Medication Adherence scale 6.91±1.35 6.96±1.27 .24306 7±1.32 6.79±1.37 .02094

3.3. Hispanics from US mainland vs PR

Approximately 56% of SPRINT Hispanics were living in PR and enrolled from five clinic sites on the island. Of those classified as Hispanics from the US mainland: 64 were Puerto Rican, 63 were Cuban, 111 were Mexican, 194 were of other Hispanic background, and three identified as being of mixed Hispanic backgrounds. Of those classified as Hispanic from PR, 517 were Puerto Rican, 10 were Cuban, none were Mexican, and 22 were of other Hispanic background. Hispanics on the US mainland (compared with those in PR) were more likely to be older, male, and have a high school degree or less, and less likely to have any kind of a college degree. They were also more likely to be uninsured although just as likely to be employed. Compared with mainland Hispanics, Hispanics in PR had higher SBPs and DBPs and were less likely to have their BP controlled with a lower average number of prescribed BP medications. Hispanics living in PR were less likely to have a history of clinical CVD despite higher total cholesterol, higher LDL, and higher HDL levels. Serum creatinine was lower and eGFR higher among Hispanics living in PR. Mainland Hispanics had a higher average score on overall self‐reported health status, a higher average score in regards to increased depressive symptoms, lower average cognitive scores on the MoCA and DSC assessments, and worse medication adherence according to the Morisky scale when compared with Hispanics living in PR.

3.4. Aggressiveness of treatment patterns in Hispanics on the US mainland vs PR

According to the most recent Joint National Committee guidelines, patients with stage 2 hypertension (SBP ≥160 mm Hg) should be taking at least two BP medications. Overall, in SPRINT, 43.6% of the participants with an SBP ≥160 mm Hg were taking fewer than two BP medications. This was not statistically different for Hispanics vs non‐Hispanics (50.0% vs 42.9%, P=.18) or for those in PR vs US mainland (47.1% vs 57.7%, P=.36). Overall, 82.6% of SPRINT participants were taking a thiazide diuretic, angiotensin‐converting enzyme inhibitor, or calcium channel blocker. This was significantly more among Hispanics vs non‐Hispanics (85.1% vs 82.3%, P=.03) but was not different among Hispanics living in PR vs the US mainland (84.7% vs 85.5%, P=.72). With regards to other classes of antihypertensive agents among patients not taking a thiazide diuretic, angiotensin‐converting enzyme inhibitor, or calcium channel blocker as first‐line treatment, only β‐blockers were significantly used more among Hispanics living in PR vs the US mainland (45.2% vs 27.0%, P=.02).

3.5. Predictors of BP control at baseline

Overall, approximately half of all SPRINT participants had controlled BP (<140/90 mm Hg) at baseline. This proportion did not vary significantly among Hispanics vs non‐Hispanics but was significantly lower among Hispanics in PR vs mainland Hispanics (Table 2). As detailed in Table 4, in logistic regression models that included only Hispanics, several univariate associations with baseline BP control were identified. In multivariable logistic regression models, better BP control was more likely among those with a history of clinical CVD but less likely among Hispanic participants with higher functional abilities scores. A history of clinical CVD and functional status remained associated with better BP control among Hispanics in PR; however, for mainland Hispanics, functional status was the only independent significant predictor of BP control identified. Interestingly, neither medication adherence nor insurance status was associated with BP control among any Hispanics.

Table 4.

Logistic regression of factors associated with achieved blood pressure control (<140/90 mm Hg) at baseline among Hispanic Systolic Blood Pressure Intervention Trial Participants

Hispanics Hispanics in Puerto Rico US Mainland Hispanics
Univariate analysis Multivariate analysis (n=432) Univariate analysis Multivariate analysis (n=248) Univariate analysis Multivariate analysis(n=185)
OR (95% CI) OR (95% CI) OR (95% CI) OR (95% CI) OR (95% CI) OR (95% CI)
Social demographics . . .
Age: 65–74 (vs <65) 0.87 (0.65–1.16) 0.84 (0.51–1.38) 0.83 (0.57–1.21) 0.96 (0.61–1.52) 1.13 (0.52–2.43)
Age: >75 (vs <65) 0.59 (0.42–0.84) 0.75 (0.43–1.31) 0.57 (0.33–0.97) 0.52 (0.32–0.84) 0.74 (0.35–1.54)
Male (vs female) 1.47 (1.14–1.89) 1.39 (0.91–2.13) 1.46 (1.04–2.05) 1.03 (0.55–1.9) 1.23 (0.83–1.83)
Lives with others (vs lives alone) 1.24 (0.92–1.66) 1.23 (0.82–1.86) 1.34 (0.88–2.06)
<High school (vs high school graduate or higher) 0.78 (0.58–1.05) 1.09 (0.66–1.79) 0.69 (0.45–1.07) 1.07 (0.57–1.98) 0.75 (0.5–1.14)
Employed (vs not employed) 1.43 (1.1–1.86) 1.17 (0.69–1.97) 1.49 (1.04–2.13) 1.79 (0.89–3.61) 1.3 (0.88–1.93)
Has health insurance (vs no health insurance) 0.81 (0.55–1.18) 0.99 (0.49–2) 0.92 (0.58–1.48)
Primary care provider (vs no primary care provider) 1.11 (0.62–2) 1.7 (0.76–3.83) 0.58 (0.22–1.55)
CVD history (vs no CVD history) 1.48 (1.07–2.05) 1.81 (1.11–2.97) 1.72 (1.08–2.76) 3.81 (1.9–7.9) 1.16 (0.74–1.82)
Smoker (vs nonsmoker) 1.12 (0.87–1.44) 0.98 (0.69–1.39) 1.12 (0.76–1.63)
Participates in physical activity (vs no physical activity) 1.21 (0.94–1.56) 1.19 (0.84–1.68) 1.22 (0.83–1.8)
Clinical measures . . .
No. of chronic diseases (unit increase) 1.01 (0.93–1.1) 1.05 (0.94–1.18) 0.93 (0.83–1.05)
No. of BP medications <3 (vs ≥3) 0.77 (0.57–1.04) 0.66 (0.42–1.05) 0.74 (0.48–1.13) 0.87 (0.57–1.35)
Weight: BMI <25 (vs BMI ≥25) 0.66 (0.47–0.94) 0.62 (0.36–1.06) 0.63 (0.39–1.02) 0.56 (0.26–1.14) 0.69 (0.41–1.16)
eGFR (20 mL/min/1.73 m2[1 SD]) 1 (0.99–1) 1 (0.99–1.01) 1 (0.99–1.01)
Study measures . . .
General health status 0.92 (0.8–1.06) 0.83 (0.67–1.01) 1.06 (0.77–1.48) 0.93 (0.75–1.14)
EuroQol‐5D (health utility) 0.78 (0.34–1.79) 0.94 (0.28–3.18) 0.79 (0.25–2.49)
Patient Health Questionnaire‐9 1.01 (0.98–1.04) 1.01 (0.97–1.05) 1 (0.96–1.04)
Patient satisfaction 0.86 (0.74–1.01) 0.97 (0.74–1.26) 0.88 (0.72–1.08) 0.85 (0.67–1.07)
Dementia screening . . .
Logical memory I (0‐28) 1.02 (1–1.05) 0.99 (0.94–1.04) 1.01 (0.98–1.04) 1.05 (1.01–1.09) 1.01 (0.92–1.1)
Logical memory II (0‐14) 1.02 (0.99–1.06) 1 (0.96–1.05) 1.06 (1–1.12) 1.03 (0.91–1.17)
Montreal Cognitive Assessment 1.02 (1–1.05) 1 (0.93–1.08) 1.02 (0.98–1.05) 1.04 (1–1.08) 1 (0.9–1.11)
Digit Symbol Coding 1 (0.99–1) 1 (0.99–1) 1.01 (1–1.02)
Functional assessment (Functional Activities Questionnaire) 0.9 (0.86–0.95) 0.9 (0.84–0.95) 0.91 (0.85–0.98) 0.92 (0.84–0.99) 0.9 (0.83–0.98) 0.91 (0.83–0.98)
Morisky Medication Adherence scale 1.02 (0.93–1.12) 1.06 (0.93–1.22) 1.01 (0.87–1.17)

Abbreviations: BP, blood pressure; BMI, body mass index; CI, confidence interval; CVD, cardiovascular disease; eGFR, estimated glomerular filtration rate; OR, odds ratio; SD, standard deviation.

4. Discussion

The purpose of this study was to describe the baseline characteristics of Hispanic participants in SPRINT, compare the clinical and study measures with those in non‐Hispanics, and explore the factors associated with poor BP control at study entry. Because of the impact of hypertension, the goal of SPRINT was to enroll a significant percentage of minorities, including Hispanics, as well as women and those 75 years and older. SPRINT successfully enrolled a diverse sample, including 11% (n=984) Hispanics. Although SPRINT did not a priori propose a baseline analysis by Hispanic ethnicity, given that Hispanics have been underrepresented in clinical trials in general and in BP trials in particular, it was important to report these results.

SPRINT eligibility criteria were designed to facilitate the inclusion of high‐risk populations. Our findings suggest that Hispanics did differ substantially in several baseline risk factors compared with non‐Hispanics. Hispanics enrolled in SPRINT were younger, more likely to be female, more likely to be living with others, and more likely to be of lower socioeconomic status compared with non‐Hispanics. We found that Hispanics recruited into SPRINT were more likely to be uninsured and were taking fewer antihypertensive medications at baseline despite having higher SBP values than non‐Hispanic participants. Hispanics had a worse lipid profile than non‐Hispanics and were more likely to be sedentary. Despite this, clinical CVD prevalence was similar among Hispanics and non‐Hispanics. CKD appears to be less prevalent among Hispanics, as they had higher eGFR and lower serum creatinine values compared with non‐Hispanics in SPRINT. However, less prevalent CKD was driven by the PR Hispanics, as eGFR was higher in PR vs mainland Hispanics. Clinic selection issues in PR probably accounted for some of these differences. Characteristics of non‐Hispanic blacks in SPRINT have been previously reported.20 Compared with non‐Hispanic blacks, Hispanics in SPRINT were taking fewer BP medications at enrollment and were less likely to be smokers but were as likely to have less than a high school education or be uninsured.

Hispanics are underrepresented in biomedical research, community‐based cohorts, and clinical trials; however, it appears that Hispanics enrolled in SPRINT, despite being younger, may be a particularly high‐risk subgroup with higher SBPs, worse lipid profiles, and untreated or uncontrolled BP than non‐Hispanics in SPRINT. Hispanics in the Antihypertensive and Lipid Lowering Treatment to Prevent Heart Attack Trial (ALLHAT) were also younger, more likely to be female, and of lower socioeconomic status than non‐Hispanics in that particular clinical trial.21 Given the paucity of hypertension clinical trials that have included Hispanics, we turn our attention to prior population‐based studies. In the Multi‐Ethnic Study of Atherosclerosis (MESA), BP was higher among Hispanics when compared with their non‐Hispanic white counterparts, with Hispanic adults, along with non‐Hispanic blacks, having a significantly higher prevalence of treated but uncontrolled hypertension compared with non‐Hispanic white adults.22 In the HCHS/SOL, of patients with hypertension, 50% were receiving treatment and only 32% of those treated had their hypertension under control.11 Results from SPRINT seem consistent with these prior studies. In addition, at baseline in SPRINT, Hispanics (compared with non‐Hispanics) were as likely to be satisfied with their medical care and to adhere to prescribed medication; thus, these factors were not associated with uncontrolled BP in this group at study entry.

Some data point to a health advantage among Hispanics over non‐Hispanic populations.23 Hispanics, despite an increased burden of heart disease risk factors and greater socioeconomic disadvantage, are less likely to have coronary heart disease and less likely to die from heart disease compared with non‐Hispanic whites.24 This discordance comprises the so‐called Hispanic paradox.25, 26 Among SPRINT participants, this paradox was not evident because clinical CVD prevalence was similar among Hispanics compared with non‐Hispanics. Hence, the notion of the Hispanic paradox may be flawed, perpetuating an inaccurate view of Hispanics as low risk, and not likely to impact on study power in this subgroup. Thus, SPRINT should provide important data on the effects of aggressive BP control on the differences in CVD outcomes by racial and ethnic subgroups.

The Hispanic/Latino population, a growing heterogeneous subgroup, is currently the largest US minority.27 Although Hispanics have been reported to have hypertension prevalence rates not significantly different from non‐Hispanic whites, most data have been extrapolated from Mexican Americans. The HCHS/SOL recently reported that the overall age‐adjusted hypertension prevalence rates are higher in Dominican, Puerto Rican, and Cuban adults. Mexican Americans had a significantly lower prevalence rate of hypertension compared with all other Hispanic subgroups except South Americans.11 On the US mainland, Puerto Ricans are the second largest Hispanic group following Mexicans. Compared with other US Hispanics, Puerto Ricans overall have lower median household incomes and lower homeownership rates and are more likely to live in poverty.27 Substantial differences have been reported in the demographic profiles of those born on the mainland vs those born on the island. Mainland‐born Puerto Ricans are younger, have higher household incomes, and are more likely to have attended college than their island‐born counterparts.28 In SPRINT we found opposite trends. Hispanics on the US mainland (compared with those in PR) were more likely to be older and male, more likely to have a high school degree or less, less likely to have any kind of a college degree, and more likely to be uninsured. Compared with mainland Hispanics, Hispanics living in PR were less likely to have a history of clinical CVD despite having higher SBPs and DBPs, along with being less likely to have their BP controlled and taking a lower number of prescribed BP medications than mainland Hispanics. It remains to be seen whether SPRINT outcomes will differ between Hispanics residing on the island of PR vs Hispanics on the US mainland.

Historically, BP control in Hispanics has been considerably less than that of non‐Hispanic whites and blacks.27 In HCHS/SOL, only 20% of Hispanics treated had their BP under control.29 In SPRINT, SBP was higher in Hispanics when compared with the overall cohort. Other epidemiological data suggest that more than 50% of Hispanics in the US had uncontrolled BP.1 This finding parallels baseline Hispanic results in SPRINT, with 49% of Hispanics having poor BP control (BP >140/90 mm Hg) at study entry. However, Hispanics were no more likely to have uncontrolled BP at study entry than non‐Hispanics, and the Morisky Medication Adherence Score was similar among Hispanics and non‐Hispanics in SPRINT. More likely, the disparity in higher SBPs appears to be related to Hispanics being prescribed fewer antihypertensive medications at baseline compared with non‐Hispanics (eg, provider clinical inertia) possibly due to the lower socioeconomic status of Hispanics and lack of health insurance. However, the data do show that once properly treated, rates of BP control among Hispanics are among the best. Findings from ALLHAT demonstrate that Hispanic participants had equivalent or superior BP control compared with non‐Hispanics in the setting of a clinical trial in which patients with hypertension had equal access to medical care and medication provided at no cost.21 Thus, we expect future studies of achieved BP control in SPRINT to be similar among Hispanics but possibly requiring more BP medications in Hispanics living in PR vs the US mainland. Although not statistically significant, the trend was for more aggressive BP treatment in Hispanics in PR, signalling that possibly it is not that BP treatment patterns are less aggressive in PR vs the US but that hypertension may be more severe among Hispanics of Puerto Rican/Caribbean descent vs other Hispanics.

Hispanics enrolled in SPRINT consistently had lower performance on cognitive tests than non‐Hispanics. The epidemiology of neurocognitive health among Hispanics is not well known.30 Age and socioeconomic factors, particularly education, could play a role in explaining some of the neurocognitive differences between Hispanics and non‐Hispanics. However, we found that these differences were largely maintained after statistical adjustment for sociodemographic covariates. Differential neurovascular disease burden may be another cause for our observed results (although prevalence of comorbidities, CKD, and CVD were actually lower or similar for Hispanics than non‐Hispanics). It is commonly believed that Hispanics are at increased risk for dementia compared with non‐Hispanic whites.31, 32 Although all of the cognitive testing instruments were translated, the translations may be a factor in the differences in scores. Language proficiency may also come into play where English‐language tests may be more cognitively demanding for primary‐Spanish participants. The relationship between cognitive function and BP is an area of active research, and longitudinal observational studies to date have yielded mixed results.33 An important objective of SPRINT is to assess the impact of more intensive SBP reduction on the incidence of probable dementia and cognitive function changes; analysis of these data by race should provide important information in Hispanics.

Study Limitations

Several potential limitations must be pointed out. The sole purpose of our study was to describe the makeup of the SPRINT subcohort of Hispanics; however, our data should be interpreted with caution. SPRINT enrollment was highly selective to meet explicit recruitment goals and not designed as a population‐based epidemiology survey. The SPRINT study population is not a random sample of adults with hypertension. Race and ethnicity were determined by self‐report. The majority of the Hispanic participants in SPRINT were recruited from clinics located in PR and it is also possible that clinic selection issues and regional variations in physician practice accounted for our results. Furthermore, the SPRINT sample of Hispanics in PR is not meant to be representative of all Hispanics in PR. Finally, given the SPRINT inclusion criteria, participants at baseline included those with prehypertension, untreated hypertension, and treated hypertension, a diverse group with respect to their BP status, which cannot be accounted for in this analysis. Similarly, the eligibility criteria (exclusion of people with untreated BP ≥180/110 mm Hg or treated BP ≥160/100 mm Hg) may have affected our results.

5. Conclusion

Hispanic/Latinos are underrepresented in clinical trials of BP control. SPRINT is one of the largest BP control clinical trials to date inclusive of US Hispanic/Latino adults. Our findings describe significant differences between Hispanic and non‐Hispanic participants in SPRINT that affect baseline BP control. SPRINT has the potential to provide a better understanding of predictors that influence poor BP control as well as understand the effects of lower SBP targets on clinical outcomes in this understudied population.

Conflict of Interest

The authors declare no conflicts of interest.

Acknowledgments

SPRINT is funded with federal funds from the National Institutes of Health (NIH), including the National Heart, Lung, and Blood Institute (NHLBI), the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), the National Institute on Aging (NIA), and the National Institute of Neurological Disorders and Stroke (NINDS), under contract numbers HHSN268200900040C, HHSN268200900046C, HHSN268200900047C, HHSN268200900048C, HHSN268200900049C, and Inter‐Agency Agreement Number A‐HL‐13‐002‐001. It was also supported in part with resources and use of facilities through the Department of Veterans Affairs. The SPRINT investigators acknowledge the contribution of study medications (azilsartan and azilsartan combined with chlorthalidone) from Takeda Pharmaceuticals International, Inc. All components of the SPRINT study protocol were designed and implemented by the investigators. The investigative team collected, analyzed, and interpreted the data. All aspects of manuscript writing and revision were carried out by the coauthors. The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH, the US Department of Veterans Affairs, or the US government. For a full list of contributors to SPRINT, please see the supplementary acknowledgment list: ClinicalTrials.gov identifier: NCT01206062. We also acknowledge the support from the following CTSAs funded by NCATS: CWRU: UL1TR000439, OSU: UL1RR025755, U Penn: UL1RR024134 and UL1TR000003, Boston: UL1RR025771, Stanford: UL1TR000093, Tufts: UL1RR025752, UL1TR000073, and UL1TR001064, University of Illinois: UL1TR000050, University of Pittsburgh: UL1TR000005, UT Southwestern: 9U54TR000017‐06, University of Utah: UL1TR000105‐05, Vanderbilt University: UL1 TR000445, George Washington University: UL1TR000075, University of CA, Davis: UL1 TR000002, University of Florida: UL1 TR000064, University of Michigan: UL1TR000433, Tulane University: P30GM103337 COBRE Award NIGMS. National Heart, Lung, and Blood Institute R01 HL104199, Epidemiologic Determinants of Cardiac Structure and Function among Hispanics: Carlos J. Rodriguez, MD, MPH Principal Investigator.

Rodriguez, C. J. , Still, C. H. , Garcia, K. R. , Wagenknecht, L. , White, S. , Bates, J. , Del Cid, M. , Lioudis, M. , Lopez Barrera, N. , Moreyra, A. , Punzi, H. , Ringer, R. , Cushman, W. C. , Contreras, G. , Servilla, K. and Rocco, M. for the SPRINT Research Group . (2017), Baseline blood pressure control in Hispanics: characteristics of Hispanics in the Systolic Blood Pressure Intervention Trial (SPRINT). Journal of Clinical Hypertension, 19:116–125. doi: 10.1111/jch.12942

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