Table 2.
Most Overexpressed Genes in Anaplastic Thyroid Carcinoma
| Gene symbol | Gene description | Chr location | FC1 | FC2 | FC3 | FC4 | FC5 | FC6 | FC7 |
|---|---|---|---|---|---|---|---|---|---|
| MMP1 | Matrix metallopeptidase 1 (interstitial collagenase) | chr11q22.3 | 44.2 | 23.2 | 28.1 | 10.3 | 32.6 | 54.3 | 36.1 |
| TMEM158 | Transmembrane protein 158 (gene/pseudogene) | chr3p21.3 | 34.3 | 22.5 | 22.6 | 16.7 | 19.9 | 25.5 | 20.7 |
| CXCL5 | Chemokine (C-X-C motif) ligand 5 | chr4q13.3 | 17.0 | 15.9 | 24.9 | 12.9 | 24.0 | 33.8 | 20.6 |
| ANLN | Anillin, actin binding protein | chr7p15-p14 | 15.0 | 15.6 | 22.2 | 10.2 | 19.4 | 25.2 | 14.2 |
| E2F7 | E2F transcription factor 7 | chr12q21.2 | 12.8 | 15.2 | 18.5 | 11.6 | 19.7 | 14.2 | 9.6 |
| DLGAP5 | Discs, large (Drosophila) homolog-associated protein 5 | chr14q22.3 | 8.8 | 10.9 | 14.0 | 8.1 | 14.3 | 22.6 | 12.9 |
| CEP55 | Centrosomal protein 55kDa | chr10q23.33 | 9.1 | 13.4 | 16.8 | 9.2 | 15.4 | 14.6 | 9.5 |
| RRM2 | Ribonucleotide reductase M2 | chr2p25-p24 | 8.6 | 9.1 | 16.9 | 7.7 | 15.0 | 21.8 | 8.5 |
| TFPI2 | Tissue factor pathway inhibitor 2 | chr7q22 | 14.9 | 6.7 | 6.9 | 5.5 | 7.4 | 25.6 | 20.1 |
| MME | Membrane metallo-endopeptidase | chr3q25.2 | 14.2 | 11.9 | 14.8 | 10.3 | 12.0 | 10.8 | 11.5 |
| ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | chr1q31 | 9.5 | 8.2 | 9.0 | 6.9 | 9.0 | 24.2 | 14.1 |
| UHRF1 | Ubiquitin-like with PHD and ring finger domains 1 | chr19p13.3 | 7.2 | 9.4 | 16.0 | 6.6 | 16.5 | 18.4 | 6.8 |
| MELK | Maternal embryonic leucine zipper kinase | chr9p13.2 | 7.2 | 8.4 | 15.9 | 5.8 | 13.9 | 16.4 | 9.3 |
| LOC100506303 | Uncharacterized LOC100506303 | — | 9.3 | 6.3 | 10.0 | 6.6 | 9.8 | 22.3 | 10.1 |
| TOP2A | Topoisomerase (DNA) II alpha 170kDa | chr17q21-q22 | 11.1 | 7.4 | 11.4 | 6.2 | 15.9 | 14.7 | 5.7 |
| SERPINE1 | Serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | chr7q22.1 | 13.5 | 7.8 | 7.4 | 5.9 | 8.7 | 15.1 | 12.6 |
| PBK | PDZ binding kinase | chr8p21.2 | 6.6 | 8.6 | 10.2 | 7.7 | 10.4 | 16.7 | 10.0 |
| PRR11 | Proline rich 11 | chr17q22 | 5.1 | 10.4 | 10.2 | 10.2 | 11.2 | 11.7 | 9.5 |
| NUF2 | NDC80 kinetochore complex component, homolog (S. cerevisiae) | chr1q23.3 | 6.1 | 9.0 | 9.7 | 7.0 | 9.3 | 14.6 | 12.2 |
| COL12A1 | Collagen, type XII, alpha 1 | chr6q12-q13 | 9.9 | 10.5 | 9.8 | 8.3 | 9.3 | 11.2 | 8.9 |
| CDC20 | Cell division cycle 20 | chr1p34.1 | 6.7 | 9.2 | 10.3 | 10.6 | 10.6 | 10.6 | 7.4 |
| TRIP13 | Thyroid hormone receptor interactor 13 | chr5p15.33 | 5.8 | 8.5 | 9.0 | 7.3 | 9.9 | 10.4 | 8.8 |
| NUSAP1 | Nucleolar and spindle associated protein 1 | chr15q15.1 | 6.4 | 5.2 | 9.0 | 5.1 | 10.4 | 16.2 | 5.8 |
| LOX | Lysyl oxidase | chr5q23.2 | 17.4 | 5.2 | 6.7 | 5.2 | 6.6 | 9.1 | 7.9 |
| BUB1 | BUB1 mitotic checkpoint serine/threonine kinase | chr2q14 | 5.1 | 6.5 | 7.6 | 5.0 | 7.2 | 16.2 | 9.9 |
| FOXD1 | Forkhead box D1 | chr5q12-q13 | 5.1 | 8.9 | 8.3 | 8.4 | 7.0 | 9.5 | 10.0 |
| TPX2 | Microtubule-associated, homolog (Xenopus laevis) | chr20q11.2 | 5.7 | 5.4 | 6.7 | 6.7 | 7.5 | 16.4 | 8.7 |
| BCAT1 | Branched chain amino-acid transaminase 1, cytosolic | chr12p12.1 | 6.2 | 8.0 | 11.6 | 5.2 | 9.6 | 10.1 | 5.7 |
| CDKN3 | Cyclin-dependent kinase inhibitor 3 | chr14q22 | 10.2 | 5.6 | 6.3 | 5.4 | 6.2 | 12.7 | 9.6 |
| KIF20A | Kinesin family member 20A | chr5q31 | 8.2 | 5.6 | 6.9 | 6.3 | 9.4 | 11.9 | 6.7 |
| KIF15 | Kinesin family member 15 | chr3p21.31 | 5.2 | 7.2 | 8.3 | 7.3 | 9.4 | 9.4 | 6.5 |
| KIF23 | Kinesin family member 23 | chr15q23 | 7.6 | 6.2 | 7.5 | 5.1 | 7.1 | 11.0 | 8.5 |
| FAM83D | Family with sequence similarity 83, member D | chr20q11.22 | 6.2 | 5.2 | 5.8 | 5.6 | 7.0 | 13.3 | 9.3 |
| NCAPG | Non-SMC condensin I complex, subunit G | chr4p15.33 | 6.3 | 5.9 | 6.6 | 5.8 | 6.7 | 11.4 | 9.0 |
| DEPDC1 | DEP domain containing 1 | chr1p31.2 | 5.9 | 6.4 | 6.5 | 6.4 | 6.7 | 9.0 | 8.5 |
| LOC375295 | Uncharacterized LOC375295 | chr2q31.1 | 9.1 | 6.9 | 6.2 | 5.8 | 5.9 | 5.0 | 6.1 |
All listed genes had greater than five-fold change in all seven comparisons; False Discovery Rate (FDR) adjusted p-value <0.01.
FC1: GSE65144: ATC (n = 12) vs. Normal (n = 10).
FC2: GSE29265: ATC (n = 9) vs. PTC from Chernobyl Tissue Bank (n = 10).
FC3: GSE29265: ATC (n = 9) vs. Normal from Chernobyl Tissue Bank (n = 10).
FC4: GSE29265: ATC (n = 9) vs. PTC from the Ambroise Paré Hospital, France (n = 10).
FC5: GSE29265: ATC (n = 9) vs. Normal from the Ambroise Paré Hospital, France (n = 10).
FC6: GSE33630: ATC (n = 11) vs. Normal from Chernobyl Tissue Bank (n = 45).
FC7: GSE33630: ATC (n = 11) vs. PTC from Chernobyl Tissue Bank (n = 49).
Chr, chromosome; FC, fold change.