Table 2.

Within-subjects improvement in patient reported outcome measures following endoscopic sinus surgery.

	Baseline Mean ± SD	Last Follow-up Mean ± SD	Within- subject Δ Mean ± SD	95% CI for Δ [LB, UB]	p-value
All subjects:
miniAQLQ total score (n=61)	4.6 ± 1.3	5.0 ± 1.5	0.5 ± 1.1	[0.2, 0.7]	0.002
Symptom score	4.2 ± 1.4	4.9 ± 1.6	0.7 ± 1.2	[0.3, 1.0]	<0.001
Activity score	5.3 ± 1.4	5.6 ± 1.6	0.3 ± 1.4	[0.02, 0.7]	0.056
Emotional function score	4.7 ± 1.6	5.2 ± 1.7	0.4 ± 1.2	[0.1, 0.8]	0.004
Environmental stimuli score	4.1 ± 1.6	4.4 ± 1.6	0.3 ± 1.6	[−0.1, 0.7]	0.186
ACT total score (n=52)	18.5 ± 4.9	19.8 ± 5.0	1.3 ± 4.1	[0.2, 2.4]	0.025
Subjects with preoperative uncontrolled asthma: (n=28)
miniAQLQ total score	3.9 ± 1.0	4.7 ± 1.6	0.7 ± 1.3	[0.3, 1.2]	0.004
Symptom score	3.6 ± 1.1	4.5 ± 1.7	0.9 ± 1.3	[0.4, 1.4]	0.001
Activity score	4.7 ± 1.3	5.4 ± 1.7	0.7 ± 1.6	[0.1, 1.3]	0.023
Emotional function score	4.1 ± 1.5	4.7 ± 1.9	0.6 ± 1.3	[0.1, 1.1]	0.026
Environmental stimuli score	3.4 ± 1.5	4.1 ± 1.6	0.7 ± 1.7	[0.04, 1.3]	0.036
ACT total score	15.0 ± 3.9	17.9 ± 5.8	2.9 ± 4.4	[1.2, 4.6]	0.002
All subjects CRS-specific quality of life scores: (n=61)
SNOT-22 total score	60.1 ± 19.6	26.3 ± 19.8	−33.8 ± 22.8	[−39.5, −28.1]	<0.001
Rhinologic symptoms	18.5 ± 6.4	8.3 ± 6.0	−10.2 ± 7.5	[−12.0, −8.3]	<0.001
Extra-nasal rhinologic symptoms	9.7 ± 2.9	4.9 ± 3.5	−4.8 ± 3.8	[−5.8, −3.9]	<0.001
Ear / facial symptoms	10.0 ± 5.6	4.2 ± 4.5	−5.8 ± 5.4	[−7.1, −4.4]	<0.001
Psychological dysfunction	18.2 ± 7.5	7.3 ± 7.6	−10.9 ± 8.9	[−13.1, −8.7]	<0.001
Sleep dysfunction	15.8 ± 6.0	7.3 ± 6.7	−8.5 ± 7.0	[−10.3, −6.8]	<0.001

SD, standard deviation; Δ, delta (change); LB, lower bound; UB, upper bound; CI, confidence interval; SNOT-22, 22-item SinoNasal Outcome Test; miniAQLQ, the Mini Asthma Quality of Life Questionnaire; ACT, the Asthma Control Test; Within-subject improvement in all outcome measures was evaluated using either matched pairs t-testing or Wilcoxon signed-rank testing, depending on distribution normality.