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. Author manuscript; available in PMC: 2017 Feb 21.
Published in final edited form as: Neuron. 2016 Sep 21;91(6):1260–1275. doi: 10.1016/j.neuron.2016.08.020

Figure 7. LHX6 Is Required for Activating Transcription in the SVZ and MZ of the MGE.

Figure 7

(A) Proportion of MGE, LGE, and cortex activity of +/−REs and +/+REs at E11.5.

(B) VZ, SVZ, and MZ activity of +/+REs in the MGE at E11.5. Chi-square test was used to test significance between the groups: *p < 0.05.

(C) Browser view of +/−REs with tracks; VISTA transgenic ID, NKX2-1 ChIP-seq, LHX6 ChIP-seq, H3K4me1, H3K4me3, H3K27ac, H3K27me3, UCSC genes, and mammalian conservation. Both WT and Nkx2-1cKO data are shown for H3 modifications. Called peaks are labeled with an asterisk. VISTA transgenics showing in vivo activity of +/−REs (hs187, hs271, and hs1336) at E11.5.

(D) Browser view of +/+REs with tracks; VISTA transgenic ID, NKX2-1 ChIP-seq, LHX6 ChIP-seq, H3K4me1, H3K4me3, H3K27ac, H3K27me3, UCSC genes, and mammalian conservation. Both WT and Nkx2-1cKO data are shown for H3 modifications. Called peaks are labeled with an asterisk. VISTA transgenics showing in vivo activity of +/+REs (hs550, hs623, and hs883) at E11.5.