Table 1.

Demographic and Clinical Parameters in 198 APAP-ALF patients stratified by Day 21 outcome.

	APAP Alive Day 21 (n=99)		APAP Dead Day 21 (n=99)
	N	Number (%) or median (IQR)	N	Number (%) or median (IQR)	P value
Age	99	35 (28–43)	99	40 (30–48)	0.084
Sex (female)	99	75 (76%)	99	72 (73%)	0.63
Race					0.23
White	99	83 (84%)	99	79 (80%)
African-American	99	8 (8%)	99	15 (15%)
Other	99	8 (8%)	99	5 (5%)
Organ support (days 1–7)
Mechanical ventilation	99	64 (65%)	99	93 (93%)	<0.0001
Vasopressors	99	12 (12%)	99	69 (70%)	<0.0001
Renal Replacement therapy	99	27 (27%)	99	45 (45%)	0.0078
KCC	87	7 (7%)	87	16 (16%)	0.13
Coma Grade 3/4 (Worst days 1–7)	99	61 (62%)	98	91 (93%)	<0.0001
ICP directed therapies (days 1–7)
ICP Monitor	99	12 (12%)	99	21 (21%)	0.086
Mannitol	99	22 (22%)	99	46 (46%)	0.0003
Hypertonic saline	99	11 (11%)	99	14 (14%)	0.52
Barbiturates	99	9 (9%)	99	20 (20%)	0.043
Hypothermia	99	17 (17%)	99	14 (14%)	0.56
Sedatives	99	70 (71%)	99	88 (89%)	0.0014
Blood products (days 1–7)
Red Blood Cells	99	34 (34%)	99	50 (51%)	0.021
Fresh Frozen Plasma	99	50 (51%)	99	76 (77%)	0.0001
Recombinant VIIA	99	3 (3%)	99	5 (5%)	0.72
Platelets	99	17 (17%)	99	36 (36%)	0.0023
ICU Complications (days 1–7)
Seizures	99	3 (3%)	99	21 (21%)	<0.0001
Arrhythmias	99	25 (25%)	99	38 (38%)	0.047
GI bleeding	99	8 (8%)	99	19 (19%)	0.037
Abnormal CT	15	10 (67%)	12	8 (67%)	1.00
Abnormal CXR	99	88 (89%)	99	83 (84%)	0.30
Bacteremia/Blood stream infection	99	7 (7%)	99	10 (10%)	0.61
Cause of death
Multiorgan failure			99	51 (52%)
Cerebral edema			99	38 (39%)
Unknown			99	9 (9%)
Listed for transplant	99	15 (15%)	99	23 (23%)	0.15

N: frequency. IQR: interquartile range.

ARDS: acute respiratory syndrome. CT: computed tomography. CXR; chest x-ray.