Table 2.
Patient’s self-reported disease-specific symptoms over time.
| Disease-specific symptoms (MDASI) M(sd), range |
Baseline N=66 | 4 months N=48 | 8 months N=37 | 12 months N=29 |
|---|---|---|---|---|
| Pain | 1.52 (2.85), 0–10 | 1.38 (2.38), 0–8 | 1.57 (2.90), 0–10 | 1.38 (2.32), 0–8 |
| Fatigue | 3.35 (3.15), 0–10 | 3.25 (3.11), 0–10 | 3.14 (2.77), 0–9 | 3.83 (3.24), 0–9 |
| Nausea | 0.74 (1.69), 0–8 | 0.73 (2.12), 0–10 | 0.62 (1.69), 0–8 | 0.71 (1.96), 0–8* |
| Disturbed sleep | 3.02 (3.32), 0–10 | 1.23 (2.28), 0–8 | 1.73 (2.84), 0–9 | 1.93 (2.67), 0–8 |
| Distress | 2.41 (3.21), 0–10 | 1.96 (2.58), 0–10 | 2.11 (2.87), 0–10 | 2.86 (3.38), 0–10 |
| Shortness of breath | 0.64 (1.89), 0–10 | 0.62 (1.41), 0–5 | 0.51 (1.39), 0–7 | 0.64 (1.83), 0–8* |
| Remembering | 2.62 (2.83), 0–10 | 2.56 (2.69), 0–10 | 2.24 (2.55), 0–8 | 3.03 (2.91), 0–9 |
| Lack of appetite | 1.28 (2.41), 0–9* | 2.17 (3.32), 0–10 | 0.70 (1.70), 0–8 | 1.38 (2.72), 0–9 |
| Drowsiness | 2.58 (3.14), 0–10 | 2.40 (2.70), 0–9 | 2.32 (2.89), 0–10 | 3.31 (3.25), 0–10 |
| Dry mouth | 1.50 (2.27), 0–10 | 1.44 (2.41), 0–10 | 1.95 (2.88), 0–10 | 1.97 (3.09), 0–10 |
| Sad | 2.35 (3.12), 0–10 | 1.48 (2.39), 0–10 | 2.05 (3.06), 0–10 | 2.38 (3.09), 0–9 |
| Vomiting | 0.17 (1.02), 0–8 | 0 (0), 0–0 | 0.03 (0.16), 0–1 | 0.29 (1.51), 0–8* |
| Numbness or tingling | 0.77 (1.57), 0–6 | 0.46 (1.30), 0–6 | 0.27 (0.99), 0–5 | 0.83 (2.47), 0–10 |
| Weakness | 2.02 (2.99), 0–10 | 2.00 (2.68), 0–10 | 2.05 (2.76), 0–10 | 2.55 (2.93), 0–9 |
| Understanding | 1.68 (2.82), 0–10 | 1.69 (2.60), 0–9 | 1.54 (2.60), 0–10 | 1.61 (2.53), 0–9* |
| Speaking | 1.35 (2.53), 0–10 | 0.96 (1.91), 0–8 | 1.27 (2.61), 0–10 | 1.48 (2.38), 0–9 |
| Seizures | 0.03 (0.25), 0–2 | 0.23 (1.33), 0–9 | 0.46 (1.98), 0–10 | 0.31 (1.67), 0–9 |
| Concentrating | 2.11 (2.61), 0–10 | 2.33 (2.55), 0–10 | 1.86 (2.61), 0–10 | 2.66 (3.00), 0–10 |
| Vision | 1.27 (2.43), 0–10 | 1.02 (2.16), 0–8 | 0.97 (1.92), 0–8 | 1.28 (2.70), 0–9 |
| Appearance | 1.00 (2.42), 0–10 | 2.17 (3.32), 0–10 | 0.51 (1.74), 0–9 | 0.52 (2.05), 0–10 |
| Bowel pattern | 0.92 (2.19), 0–10 | 1.08 (2.52), 0–10 | 0.97 (2.06), 0–9 | 0.54 (1.75), 0–9* |
| Irritability | 2.48 (2.91), 0–10 | 2.19 (2.57), 0–10 | 2.46 (3.18), 0–10 | 2.17 (3.11), 0–9 |
| General activity | 3.88 (3.34), 0–10 | 3.04 (2.86), 0–10 | 2.54 (3.10), 0–10 | 1.89 (2.82), 0–8* |
| Mood | 2.64 (3.15), 0–10 | 2.44 (2.78), 0–10 | 2.38 (3.23), 0–10 | 1.64 (2.66), 0–8* |
| Work | 3.62 (3.51), 0–10 | 3.40 (3.14), 0–10 | 3.03 (3.41), 0–10* | 2.11 (2.95), 0–10* |
| Relationships | 1.58 (2.61), 0–10 | 1.94 (2.67), 0–9 | 1.70 (2.78), 0–10 | 0.86 (2.03), 0–8* |
| Walking | 2.11 (3.05), 0–10 | 2.44 (3.05), 0–9 | 2.19 (3.08), 0–10 | 1.46 (2.62), 0–8* |
| Enjoyment of life | 2.80 (3.27), 0–10 | 2.92 (3.42), 0–10 | 2.51 (3.44), 0–10 | 1.96 (2.97), 0–9* |
*
one case missing