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. Author manuscript; available in PMC: 2017 Mar 3.
Published in final edited form as: Oncogene. 2016 Aug 22;36(9):1232–1244. doi: 10.1038/onc.2016.288

Figure 7. Yap expression correlates with expression of MDSC-related genes and predicts survival in human PDAC.

Figure 7

(a) Heatmap of unsupervised hierarchical clustering analysis of expression of 40 MDSC-related genes in TCGA primary PDAC tumor samples with RNAseq expression information (n=179). Three major clusters are identified as “Low” (n=19), “Medium” (n=63), or “High” (n=97) .

(b) Relative YAP mRNA levels in TCGA primary PDAC tumors classified as either MDSC “High” or MDSC “Low” as in (a).

(c) Kaplan-Meier overall survival curve of PDAC patients with either “High” (n=71) or “Low” (n=16) MDSC expression profiles.

(d) Kaplan-Meier survival curve of PDAC patients stratified by Low (n=39), Medium (n=98), or High (n=10) relative YAP expression.