Skip to main content
. Author manuscript; available in PMC: 2017 Mar 3.
Published in final edited form as: Oncogene. 2016 Aug 22;36(9):1232–1244. doi: 10.1038/onc.2016.288

Figure 8. Yap orchestrates an immune suppressive microenvironment in Kras mutant pancreas by promoting the expression of MDSC-promoting cytokines.

Figure 8

Schematic representation of the crucial function of Yap as a master switch of an ongenic Kras secretome that promotes the accumulation of immune suppressive MDSCs and TAMs and downregulates antigen-presenting macrophages, leading to suppression of CTLs.