Dr. Anisha Agarwal, Dr. Neha Singla, Dr. Sandeep Grover
Department of Psychiatry, PGIMER, Chandigarh. Email Id: anishaa1089@gmail.com
Background: Subjective evaluation of a treatment is very important determinant of long term continuation of treatment. Little is known about patient's subjective perception about clozapine. Aim: To evaluate the patient's own perception about effect of clozapine on their symptoms, side effects of clozapine, investigations required for clozapine monitoring and functioning.
Methodology: 45 patients receiving clozapine for varying duration were evaluated on a self designed questionnaire to understand their perception about clozapine. The questionnaire included 45 statements with “yes” and “no” options.
Results: The mean age of patients was 32.35 (SD-10.2) years and the mean duration of education was 13.6 (SD-3.12) years. More than half were males (53.3%), currently single (73.3%) and from urban locality (73.3%). Majority of the patients reported improvement in their hallucination (82.2%) and delusions (93.3%). More than half (57.8%) of the patients reported that they were feeling like their premorbid self. Two-third (66.7%) of the patients reported that because of clozapine their functioning has improved. Majority of the patient reported that with clozapine they feel less tense (95.6%), have clear thinking process (80%), have less concentration difficulties (75.6%). Majority of patient felt that stopping clozapine can worsen their condition (75.6%) and their life would be ruined if they stop clozapine (55.6%). More than two-third (68.9%) reported that the benefits of clozapine outweigh the side effects, more than half (53.3%) reported that clozapine was delayed for their condition and majority (91.1%) reported that clozapine should not be relapsed with any other antipsychotic. Majority of participants reported that with clozapine there is improvement in their work output (66.7%), attitude and behaviour towards others (91.1%) and compliance (91.1%). More than half (57.8%) of patients were not distressed with repeated blood investigations while receiving clozapine. Overall 91.1% were happy with taking clozapine. More than half (57.8%) reported that clinicians should not wait for treatment resistance to consider starting clozapine.
Conclusion: In general, majority of the patients are satisfied with receiving clozapine. Hence, clinicians should not withhold clozapine in needy patients, because of fear of its unacceptability by the patients.
Keywords: Clozapine, Perception.