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. 2016 Sep 12;72(3):444–452. doi: 10.1111/all.13005

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© 2016 The Authors. Allergy Published by John Wiley & Sons Ltd.

This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Sucnr1 ^−/− mice develop milder K/BxN serum and mBSA‐induced arthritis. (A) Inflammatory arthritic response in paws from wt (black circles, n = 6) and Sucnr1 ^−/− (white circles, n = 6) mice after injection of K/BxN serum. Analysis using Welch‐corrected, unpaired Student's t‐test. Representative Giemsa staining of hind paws from wt (severe edema and inflammation; see asterisks) and Sucnr1 ^−/− mice (no edema and reduced inflammation). (B) Inflammatory arthritic response in knees (ratios of antigen challenged vs control) from wt (black circles, n = 5) and Sucnr1 ^−/− (white circles, n = 5) mice after mBSA challenge. Analysis using unpaired Student's t‐test. Representative Giemsa staining of knees from wt (severe inflammation; see asterisks) and Sucnr1 ^−/− (reduced inflammation) mice.