Table 1. Demographic and clinical characteristics of the subjects.
| PHC (n=353) | LC (n = 331) | CH (n = 213) | NC (n= 332) | P | |
|---|---|---|---|---|---|
| Age (mean ± SD, years) | 52.9 ± 12.9 | 50.8 ± 12.0* | 36.7 ± 12.7** | 47.0 ± 17.6** | < 0.01a |
| Gender [n (%)] | |||||
| Male | 290 (82.2) | 260 (78.5) | 166 (77.9) | 184 (55.4) | < 0.001b |
| Female | 63(17.8) | 71(21.5) | 47(22.1) | 148 (44.6) | |
| Etiology [n (%)] | |||||
| HBV | 305 (86.4) | 263 (79.5) | 200 (93.9) | - | < 0.001b |
| HCV | 0 (0.0) | 4 (1.2) | 12 (5.6) | - | < 0.001c |
| Alcohol | 4 (1.1) | 10 (3.0) | 0 (0.0) | - | 0.001c |
| Schistosomiasis | 0 (0.0) | 3 (0.9) | 0 (0.0) | - | 0.043c |
| Mixed | 11(3.0) | 39 (11.8) | 1 (0.5) | - | < 0.001c |
| Unknown | 33 (9.4) | 12 (3.6) | 0 (0.0) | - | < 0.001c |
| AFP (μg/L) | 367.6 ± 517.7 | 12.8 ± 50.6** | 63.6 ± 163.0** | 2.2 ± 1.1** | < 0.01a |
| Hepatic function tests (mean ± SD) | |||||
| ALT(U/L) | 60.2 ± 95.7 | 54.9 ± 173.6 | 262.8 ± 259.0** | 19.2 ± 9.2** | < 0.01a |
| AST(U/L) | 86.6 ± 131.1 | 62.7 ± 116.4** | 148.4 ± 158.0** | 22.5 ± 4.9** | < 0.01a |
| TBIL(μmol/L) | 29.5 ± 49.7 | 38.0 ± 71.2 | 59.2 ± 94.4** | 10.1 ± 3.6** | < 0.01a |
| DBIL(μmol/L) | 17.8 ± 35.4 | 21.9 ± 45.0 | 38.6 ± 68.6** | 4.3 ± 1.4** | < 0.01a |
| TP(g/L) | 65.5 ± 6.9 | 61.0 ± 9.3** | 65.7 ± 7.2 | 73.9 ± 3.6** | <0.01a |
| ALB(g/L) | 36.1 ± 6.0 | 31.7 ± 6.0** | 38.1 ± 5.6** | 47.1 ± 2.8** | < 0.01a |
| GLB(g/L) | 29.4 ± 6.2 | 29.4 ± 7.8 | 27.6 ± 5.2** | 26.8 ± 2.9** | < 0.01a |
| Child-Pugh grade [n (%)] | |||||
| A | 284 (80.5) | 174 (52.6) | 141 (66.2) | - | < 0.01b |
| B | 41 (11.6) | 65 (19.6) | 42 (19.7) | - | |
| C | 28 (7.9) | 92 (27.8) | 30 (14.1) | - | |
| Blood cell analyses | |||||
| WBC(109/L) | 6.3 ± 3.6 | 4.3 ± 2.6** | 5.4 ± 1.9** | 6.3 ± 1.5 | < 0.001a |
| RBC(1012/L) | 4.1 ± 0.9 | 3.5 ± 0.9** | 4.5 ± 0.7** | 4.8 ± 0.5** | < 0.001a |
| Hb(g/L) | 121.0 ± 24.5 | 98.4 ± 25.2** | 134.9 ± 19.8** | 141.9 ± 13.2** | < 0.001a |
| PLT(109/L) | 157.3 ± 92.1 | 91.2 ± 76.0** | 163.1 ± 66.5 | 218.3 ± 49.9** | < 0.001a |
Note:
*
P < 0.05,
**
P < 0.01, compared with PHC.
a
One-way ANOVA test;
b
Pearson chi-squared test;
c
Fisher's exact test.
PHC: primary hepatic carcinoma; LC: liver cirrhosis; CH: chronic hepatitis; NC: normal control; HBV: hepatitis B virus; HCV: hepatitis C virus; AFP: alpha-fetoprotein; ALT: alanine aminotransaminase; AST: aspartate aminotransaminase; TBIL: total serum bilirubin; DBIL: direct serum bilirubin; TP: total serum protein; ALB: serum albumin; GLB: serum gamma-globins; WBC: white blood cell; RBC: red blood cell; Hb: hemoglobin; PLT: platelet.