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Clustered nanoparticles with extracellular pH-triggered size shrinkage and intracellular-activatable drug release. (A) Chemical structure and schematic of the iCluster/Pt. (B) TEM images of acid-triggered dendrimers released from iCluster. (C) pH- and redox-induced dendrimers liberation and Pt release. (D) Confocal images of liberated dendrimers penetration into tumors. Adapted from Ref 117 with permission from National Academy of Sciences.
