To the Editor,
I have read with great interest the article entitled “Comparison of health-related quality of life among patients using novel oral anticoagulants or warfarin for non-valvular atrial fibrillation,” published online in Anatol J Cardiol 2015 Jul 14. (Epub ahead of print) by Balcı et al. (1). In their study, the authors reported that warfarin-treated patients had higher levels of self-reported symptoms of depression and anxiety and compromised health-related quality of life compared with novel oral anticoagulant (NOAC)-treated patients. I have the following comments and concerns:
In previous studies, it has been reported that the quality of life was significantly reduced in atrial fibrillation patients compared with that of healthy subjects (2). Therefore, the authors should state if there was any difference between the two groups in terms of atrial fibrillation duration at the beginning of the study. In addition, many cardiovascular drugs have been reported to cause depression and anxiety. In a study by Rathman et al. (3), it has been demonstrated that prescription of calcium channel blockers and beta-blockers, which are widely used for rate control in atrial fibrillation patients, can increase the risk of depression in diabetic patients. I was wondering if there was any difference between warfarin-treated patients and NOAC-treated patients in terms of using these cardiovascular medications.
Furthermore, it is well established that the risk of atrial fibrillation is closely associated with thyroid activity, and the prevalence of thyroid dysfunction in patients with atrial fibrillation was in the range of 0%–24% (4, 5). In addition, it has been shown that thyroid dysfunction itself may impair the quality of life and cause psychological symptoms. Therefore, I think that patients with hyperthyroidism and hypothyroidism should be excluded from the study.
Finally, electrical cardioversion can cause psychological discomfort in atrial fibrillation patients. Is there any attempted cardioversion procedure in the last month before beginning the study and is there any difference between two groups in terms of attempted cardioversion procedure? It would be helpful if the authors provided this information.
In conclusion, despite the aforementioned limitations, NOAC therapy seems to be psychologically better accepted than warfarin therapy in non-valvular atrial fibrillation patients.
References
- 1.Balcı KG, Balcı MM, Canpolat U, Şen F, Akboğa MK, Süleymanoğlu M, et al. Comparison of health-related quality of life among patients using novel oral anticoagulants or warfarin for non-valvular atrial fibrillation. Anatol J Cardiol. 2015 Jul 14; doi: 10.5152/AnatolJCardiol.2015.6334. Epub ahead of print. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 2.Dorian P, Jung W, Newman D, Paquette M, Wood K, Ayers GM, et al. The impairment of health-related quality of life in patients with intermittent atrial fibrillation: implications for the assessment of investigational therapy. J Am Coll Cardiol. 2000;36:1303–9. doi: 10.1016/s0735-1097(00)00886-x. [DOI] [PubMed] [Google Scholar]
- 3.Rathmann W, Haastert B, Roseman JM, Giani G. Cardiovascular drug prescriptions and risk of depression in diabetic patients. J Clin Epidemiol. 1999;52:1103–9. doi: 10.1016/s0895-4356(99)00082-7. [DOI] [PubMed] [Google Scholar]
- 4.Siebers MJ, Drinka PJ, Vergauwen C. Hyperthyroidism as a cause of atrial fibrillation in long-term care. Arch Intern Med. 1992;152:2063–4. [PubMed] [Google Scholar]
- 5.Cobler JL, Williams ME, Greenland P. Thyrotoxicosis in institutionalized elderly patients with atrial fibrillation. Arch Intern Med. 1984;144:1758–60. [PubMed] [Google Scholar]