To the Editor,
We congratulate the authors for their study entitled “Preoperative oral pentoxifylline in case of coronary artery bypass grafting with left ventricular dysfunction (ejection fraction equal to/less than 30%),” published in Anatol J Cardiol 2015; 15: 1014-9. This study evaluated the feasibilty of pentoxifylline when patients with low ejection fraction are considered (1). Systemic inflammatory response is one of the basic parameters that affect the postoperative results of coronary bypass surgery. In this context, pentoxifylline may have positive effects through the inhibition of some of the inflammatory cytokines (2–4). However, the study of Mansourian et al. (1) reveals another interesting result, i.e., a statistical decrease of blood transfusion in the pentoxifylline group. None of the similar studies have obtained this result. How do the authors explain that?
Author`s Reply
Authors of this mentioned article did not send any reply for this Letter to the Editor despite our persistent request.
References
- 1.Mansourian S, Bina P, Fehri A, Karimi AA, Boroumand MA, Abbasi K. Preoperative oral pentoxifylline in case of coronary artery bypass grafting with left ventricular dysfunction (ejection fraction equal to/less than 30%) Anatol J Cardiol. 2015;15:1014–9. doi: 10.5152/akd.2014.5883. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 2.Raja SG, Berg GA. Impact of off-pump coronary artery bypass surgery on systemic inflammation:current best available evidence. J Card Surg. 2007;22:445–55. doi: 10.1111/j.1540-8191.2007.00447.x. [DOI] [PubMed] [Google Scholar]
- 3.Wan IY, Arifi AA, Wan S, Yip JH, Sihoe AD, Thung KH, et al. Beating heart revascularization with or without cardiopulmonary bypass:Evaluation of inflammatory response in a prospective randomized study. J Thorac Cardiovasc Surg. 2004;127:1624–31. doi: 10.1016/j.jtcvs.2003.10.043. [DOI] [PubMed] [Google Scholar]
- 4.Wehlin L, Vedin J, Vaage J, Lundahl J. Activation of complement and leukocyte receptors during on- and off-pump coronary artery bypass surgery. Eur J Cardiothorac Surg. 2004;25:35–42. doi: 10.1016/s1010-7940(03)00652-3. [DOI] [PubMed] [Google Scholar]