Skip to main content
NCBI home page
Proceedings of the National Academy of Sciences of the United States of America logoLink to Proceedings of the National Academy of Sciences of the United States of America
. 1969 May;63(1):123–128. doi: 10.1073/pnas.63.1.123

EVIDENCE FOR CONTROL OF THE RATE OF NUCLEAR DNA SYNTHESIS BY THE NUCLEAR MEMBRANE IN EUKARYOTIC CELLS*

Max Alfert 1, Nirmal K Das 1
PMCID: PMC534010  PMID: 5257957

Abstract

Rates of DNA synthesis in root tip cells of diploid and autotetraploid snapdragon (Antirrhinum majus) seedlings and in diploid and tetraploid (mononucleate and bidiploid-nucleate) regenerating mouse-liver cells have been studied. The increase in this rate in the tetraploid cells is closely correlated with the increase in nuclear surface area, but not with the nuclear volume; this suggests a possible control of the rate of DNA synthesis by the nuclear membrane.

Full text

PDF
123

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ALFERT M., GESCHWIND I. I. The development of polysomaty in rat liver. Exp Cell Res. 1958 Aug;15(1):230–232. doi: 10.1016/0014-4827(58)90079-x. [DOI] [PubMed] [Google Scholar]
  2. CAMERON I. L., STONE G. E. RELATION BETWEEN THE AMOUNT OF DNA PER CELL AND THE DURATION OF DNA SYNTHESIS IN THREE STRAINS OF TETRAHYMENA PYRIFORMIS. Exp Cell Res. 1964 Dec;36:510–514. doi: 10.1016/0014-4827(64)90307-6. [DOI] [PubMed] [Google Scholar]
  3. Comings D. E. The rationale for an ordered arrangement of chromatin in the interphase nucleus. Am J Hum Genet. 1968 Sep;20(5):440–460. [PMC free article] [PubMed] [Google Scholar]
  4. DAS N. K. Demonstration of a non-RNA nucleolar fraction by silver staining. Exp Cell Res. 1962 Mar;26:428–431. doi: 10.1016/0014-4827(62)90195-7. [DOI] [PubMed] [Google Scholar]
  5. Das N. K., Siegel E. P., Alfert M. On the origin of labeled RNA in the cytoplasm of mitotic root tip cells of Vicia faba. Exp Cell Res. 1965 Oct;40(1):178–181. doi: 10.1016/0014-4827(65)90310-1. [DOI] [PubMed] [Google Scholar]
  6. MENDELSOHN M. L., DOHAN F. C., Jr, MOORE H. A., Jr Autoradiographic analysis of cell proliferation in spontaneous breast cancer of C3H mouse. I. Typical cell cycle and timing of DNA synthesis. J Natl Cancer Inst. 1960 Sep;25:477–484. [PubMed] [Google Scholar]
  7. PILGRIM C., MAURER W. AUTORADIOGRAPHISCHE UNTERSUCHUNG UEBER DIE KONSTANZ DER DNS-VERDOPPLUNGS-DAUER BEI ZELLARTEN VON MAUS UND RATTE DURCH DOPPELMARKIERUNG MIT 3H- UND 14C-THYMIDIN. Exp Cell Res. 1965 Jan;37:183–199. doi: 10.1016/0014-4827(65)90169-2. [DOI] [PubMed] [Google Scholar]
  8. TAYLOR J. H. Asynchronous duplication of chromosomes in cultured cells of Chinese hamster. J Biophys Biochem Cytol. 1960 Jun;7:455–464. doi: 10.1083/jcb.7.3.455. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Troy M. R., Wimber D. E. Evidence for a constancy of the DNA synthetic period between diploid-polyploid groups in plants. Exp Cell Res. 1968 Oct;53(1):145–154. doi: 10.1016/0014-4827(68)90362-5. [DOI] [PubMed] [Google Scholar]
  10. VAN'T HOF J., SPARROW A. H. A relationship between DNA content, nuclear volume, and minimum mitotic cycle time. Proc Natl Acad Sci U S A. 1963 Jun;49:897–902. doi: 10.1073/pnas.49.6.897. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Van't Hof J. RNA synthesis during G1, S, and G2 periods of diploid and colchicine-induced tetraploid cells in the same tissue of Pisum. Exp Cell Res. 1967 Mar;45(3):638–645. doi: 10.1016/0014-4827(67)90166-8. [DOI] [PubMed] [Google Scholar]
  12. WOODARD J., RASCH E., SWIFT H. Nucleic acid and protein metabolism during the mitotic cycle in Vicia faba. J Biophys Biochem Cytol. 1961 Feb;9:445–462. doi: 10.1083/jcb.9.2.445. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Proceedings of the National Academy of Sciences of the United States of America are provided here courtesy of National Academy of Sciences

RESOURCES