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. 2016 Aug 25;7(41):66512–66524. doi: 10.18632/oncotarget.11614

Figure 5. The effect of Skp2 overexpression on cell migration.

Figure 5

(A) Left panel: The wound healing assay was conducted to test the cell migration after Skp2 cDNA transfection and rottlerin treatment. Control: pcDNA3.1. cDNA: Skp2 cDNA; Both: Skp2 cDNA+rottlerin. Right panel, Quantitative results are illustrated for left panel. *P < 0.05, compared with control; #P < 0.05 compared with rottlerin treatment alone or Skp2 cDNA transfection alone. (B) Left panel, the expression of Skp2 and its target p21 was measured by Western blotting in breast cancer cells with Skp2 cDNA transfection and rottlerin treatment. Right panel, Quantitative results are illustrated for left panel. *P < 0.05, compared with control; #P < 0.05 compared with rottlerin treatment alone or Skp2 cDNA transfection alone.