Figure 1. Co-occurrence of chromosome 7 abnormalities and recurrent driver mutations.

A. Survival (Kaplan Meier) after diagnosis of MDS patient cohort with chromosome 7 abnormalities grouped as −7/del(7q) only (n = 15); or as −7/del(7q) + ≥ 1 cytogenetic aberration (n = 20). B. Co-occurrence map of −7 and del(7q) with oncogenic mutations (empty boxes) and truncating/unknown mutations (hatched\scored boxes) as described in supplementary methods. C. Computational prediction of fraction of cells with specified genetic lesions, within total BM mononuclear cells from patients with isolated −7 or isolated del(7q). Patients were grouped based on predicted hierarchy of genomic lesions. Error bars indicate 95% confidence interval (CI).