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. 2016 Sep 24;7(45):73101–73113. doi: 10.18632/oncotarget.12231

Figure 6. SH3GL3 regulates the expression of stem cell markers and drug resistance genes.

Figure 6

Gene expression of Nanog, OCT4 and SOX2 was determined in the H929 cells infected with SH3GL3 cDNA (A) or U266 cells infected with SH3GL3 shRNA (B). qRT-PCR analysis showed the expression of the multi-drug resistance genes, ABCC3 and ABCB1, in the H929 cells infected with SH3GL3 cDNA (C) or U266 with SH3GL3 shRNA (D). The cells infected with SH3GL3 cDNA (E) or shRNA (F) were treated with BTZ (10 nM) and cell viability was determined using MTT assay. The relative value was calculated as the ratio of treated cells and vector control. All experiments have been repeated 3 times, Mean ± SE, **p < 0.01, *p < 0.05.