Table 1. Characteristics of studies in the meta-analysis.
| Author | Year | Ethnicity | Genotyping method | Cancer type | Case/control | Control source | HWE | Quality score (0–15) | Polymorphism site |
|---|---|---|---|---|---|---|---|---|---|
| Wynendaele [14] | 2010 | Caucasian | PCR-RFLP | OC | 154/154 | HB | P = 0.982 | 7 | rs4245739 |
| Yu [7] | 2011 | Caucasian | TaqMan | SCCHN | 1075/1079 | HB | P = 0.084 for rs11801299, P = 0.712 for rs1380576, P = 0.398 for rs10900598 | 11 | rs11801299, rs1380576, rs10900598 |
| Oliveira [6] | 2012 | Caucasian, Mullato, Black | PCR/RFLP | RB | 104/104 | PB | P = 0.683 for rs116197192, P = 0.802 for rs4252668 | 8 | rs116197192, rs4252668 |
| Song [11] | 2012 | Asian | MassArray | BC | 124/101 | HB | P = 0.862 | 7 | rs1563828 |
| Wang [8] | 2012 | Caucasian | TaqMan | Oral cancer | 320/321 | HB | Agreement with HWE* | 11 | rs11801299, rs1380576, rs10900598 |
| Yu [9] | 2012 | Caucasian | TaqMan | SCCHN | 380/335 | HB | P = 0.303 for rs11801299, P = 0.502 for rs1380576, P = 0.669 for rs10900598 | 10 | rs11801299, rs1380576, rs10900598 |
| Zhang [12] | 2012 | Asian | RT-PCR | NPC | 210/200 | PB | P = 0.944 | 10 | rs1563828 |
| Garcia [22] | 2013 | Caucasian | Illumina array | BC | 6512/41451 | Mixed | P = 0.183 | 11 | rs4245739 |
| Liu [15] | 2013 | Asian | PCR-RFLP | BC | 800/800 (Jinan); 300/600 (Huaian) | PB | P = 0.505 for Jinan, P = 0.483 for Huaian | 13 | rs4245739 |
| Zhou [16] | 2013 | Asian | PCR-RFLP | ESCC | 540/550 (Jinan); 588/600 (Huaian) | PB | P = 0.740 for Jinan, P = 0.379 for Huaian | 13 | rs4245739 |
| Fan [17] | 2014 | Asian | PCR-RFLP | NHL | 200/400 | PB | P = 0.487 | 12 | rs4245739 |
| Thunell [13] | 2014 | Caucasian | TaqMan | HCM | 50/799 | PB | P = 0.725 | 11 | rs1563828 |
| Feng [18] | 2014 | Asian | PCR-RFLP | GN | 419/494 | HB | P = 0.561 | 10 | rs4245739 |
| Gansmo [19] | 2015 | Caucasian | LightSNiP assay | BC (n = 1,717); LC (n = 1,331); CC (n = 1,531); PC (n = 2,500) | 7079/3747 | PB | P = 0.566 | 13 | rs4245739 |
| Gao [20] | 2015 | Asian | PCR-RFLP | LC | 320/640 (Jinan); 200/400 (Huaian) | PB | P = 0.399 for Jinan, P = 0248 for Huaian | 10 | rs4245739 |
| Wu [10] | 2015 | Asian | TaqMan | GN | 642/720 | PB | P = 0.46 | 13 | rs1380576 |
| Gansmo [21] | 2016 | Caucasian | LightSNiP assay | EC (n = 1404); OC (n = 1385) | 2789/1870 | PB | P = 0.106 | 13 | rs4245739 |
*
This study only offered dominant-model data for rs11801299, rs1380576, and rs10900598, thus the p value of HWE were not calculated.
BC: breast cancer, CC: colon cancer, EC: endometrial cancer, ESCC: esophageal squamous cell carcinoma, GN: gastric neoplasms, HB: hospital based, HCM: hereditary cutaneous melanoma, LC: lung cancer, NHL: non-Hodgkin lymphoma, NPC: nasopharyngeal carcinoma, OC: ovarian carcinomas, PB: population based, PC: prostate cancer, RB: retinoblastoma, RT-PCR: reverse transcription-PCR, SCCHN: squamous cell carcinoma of the head and neck, SCLC: small cell lung cancer