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. 2016 Sep 23;7(44):71477–71490. doi: 10.18632/oncotarget.12216

Figure 8. KLF4 is downregulated in NPM1-mutated AML.

Figure 8

(A) Comparison by t test of relative KLF4 mRNA expression in 60 NK-AML patients from the TCGA human AML dataset with (n = 20) and without (n = 40) NPM1-mutation. (B) Expression of KLF4 mRNA in primary AML patients with (n = 4) and without (n = 8) NPM1-mutation assessed by qRT-PCR. Levels of KLF4 protein in (C) THP-1 cells with NPM1-mA overexpression and (D) in OCI-AML3 cells with NPM1-mA knockdown measured by western blot. Three independent experiments were performed.