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. 2016 Sep 28;7(44):71754–71760. doi: 10.18632/oncotarget.12330

Figure 5. Effects of myricetin on catalase and superoxide dismutase in oxidative stress Legend.

Figure 5

(Panel A). Myricetin induced a 50% decrease in the mRNA expression level of catalase in diabetic fibroblasts. Panel B. Myricetin induced a 64% decrease in the mRNA expression level of superoxide dismutase in diabetic fibroblasts. These data indicate that the mRNA levels of both catalase and superoxide dismutase decrease in the presence of 3 μM myricetin. Catalase and superoxide dismutase are involved in the induction of cellular oxidative stress, which is attributed to a rise in MMP expression and activation. Condition: The cells were incubated with 3 μM myricetin for four days, and then the expression levels of catalase and superoxide dismutase were examined by qRT-PCR. The 2−ΔΔCT method was used to analyze relative changes in gene expression.