Table 1. Relative changes in abundance of different proteins with at 1.5-fold between serum samples of PD patients and healthy controls.
Spot no.a | Protein identification | GI Accession no.b | Mascot Scorec | Coverage (%)d | Folde | t- testf |
---|---|---|---|---|---|---|
1 | Apolipoprotein A-IV | 71773110 | 131 | 42 | −2.86 | 0.0005 |
7 | Serotransferrin | 4557871 | 126 | 32 | 2.13 | 0.0031 |
9 | Apolipoprotein A-I | 4557321 | 149 | 64 | −2.02 | 0.0002 |
17 | Ras-related protein Rab-35 | 5803135 | 65 | 58 | 9.90 | 0.0017 |
39 | Golgi integral membrane protein 4 | 7657138 | 61 | 13 | 1.54 | 0.0035 |
40 | Protein disulfide-isomerase A4 | 4758304 | 68 | 40 | 1.77 | 0.0005 |
43 | Solute Carrier Family 25, Member 5 | 46095315 | 56 | 45 | 1.97 | 0.0031 |
62 | Transthyretin | 4507725 | 95 | 73 | 2.52 | 0.0010 |
68 | Ceruloplasmin | 4557485 | 120 | 27 | −2.14 | 0.0008 |
86 | Trans-Golgi network integral membrane protein 2 | 332205949 | 57 | 11 | 3.63 | 0.0012 |
89 | Complement C3 | 115298678 | 94 | 16 | −1.76 | 0.0006 |
90 | Epidermal growth factor receptor substrate 15 | 4503593 | 62 | 23 | −1.79 | 0.0002 |
95 | Prolyl endopeptidase-like | 153217451 | 57 | 36 | 1.64 | 0.0088 |
137 | Apolipoprotein A-II | 4502149 | 74 | 87 | 1.99 | 0.0003 |
172 | 26S protease regulatory subunit 7 | 547930 | 61 | 69 | −3.13 | 0.0003 |
209 | Protein unc-45 homolog A | 74761419 | 64 | 11 | 1.63 | 0.0057 |
211 | Ras-related protein Rab-39 | 39930371 | 62 | 50 | −1.75 | 0.0070 |
260 | Vitamin D-binding protein | 324021743 | 70 | 29 | 1.89 | 0.0001 |
281 | Alpha-2-macroglobulin | 66932947 | 68 | 31 | −1.73 | 0.0000 |
301 | Haptoglobin | 386783 | 65 | 27 | −1.64 | 0.0029 |
Refers to the master spot number on the 2D-DIGE generated by DeCyder image analysis software.
Accession number from NCBInr database.
Score was calculated by Mascot search engine and related to the probability assignment.
Coverage indicates the ratio of matched peptides in the protein sequence.
Fold in ratio of the protein abundance between PD and control group.
Independent tests between PD and healthy control group.