Figure 7. L-mimosine administration attenuates renal ischemia-reperfusion injuries.

The 6-8 week male C57BL/6J mice, pretreated with L-mimosine (L-Mim, 50 mg/kg, “IR+L-Mim”) or vehicle control (10% NaHCO₃, “IR+Veh”), were subjected to ischemia reperfusion operation. After 24h, serum creatinine (Scr) level was analyzed A; HE staining were performed on kidney slices, and History scores were calculated B; Expressions of listed proteins in fresh kidney slices were tested by Western blot C. and E; Level of TNF-α and IL-10 in the fresh kidney slices was tested by ELISA assay D. Sham-operated mice served as controls. Protein expression was normalized to β-actin (n = 10). *P < 0.05 vs. “IR+Veh” group (C-F); ^# P < 0.01 vs. “IR+Veh” group (C-F);