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. 2016 Jul 21;7(34):54838–54851. doi: 10.18632/oncotarget.10761

Figure 1. MiR-34b/c cluster and miR-449a are down-regulated in NPC samples and NPC cell lines.

Figure 1

(Upper line) The real time RT-PCR determination of miR-34 cluster and miR-449a expression in different development stages of NPC (n = 45) compared with the non-tumor nasopharyngeal epithelial (normal, n = 10). I–II (n = 13), III (n = 16) or IV (n = 16): NPC samples with clinical stage I–II, III or IV disease. Human U6 snRNA was used as an internal control and for normalization of the data. The data are shown as the mean ± SD (*P < 0.05; **P < 0.01; ***P < 0.001, ANOVA test). (Bottom line) The real time RT-PCR was performed to validate the expression of miR-34 cluster and miR-449a in the NPC cell lines and the immortalized normal nasopharynx epithelial NP69 cells. The expression of miRNAs was normalized to U6.