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. 2016 Sep 16;7(43):69384–69396. doi: 10.18632/oncotarget.12082

Figure 2. WWOX expression was correlated with rs11545028 genotypes in oral cancer patients.

Figure 2

(A) Two luciferase reporter vectors with either the rs11545028 C allele or the rs11545028 T allele were transfected to HSC-3, OECM-1 and SCC-9 oral cancer cells lines. Data are mean values with standard deviation from at least three independent experiments. (B) WWOX mRNA expression in cancer tissue of 34 OSCC patients was analyzed by quantitative real time-PCR assay. Numbers in parentheses indicate the number of cases. (C) Weak cytoplasmic WWOX expression in OSCC. (D) Strong cytoplasmic WWOX expression in OSCC. (E) The OSCC specimens with rs11545028 C/C have higher WWOX expression, while specimens with rs11545028 C/T or T/T have lower WWOX expression (p=0.022).