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. 2016 Sep 2;7(43):69565–69578. doi: 10.18632/oncotarget.11829

Figure 8. Increased uPAR levels in human MM tissues and in serum of MM patients.

Figure 8

(A) Immunohistochemical analysis of uPAR and pAKT in human MM tissue-array in comparison to benign pleural lesions (bar = 50 μm). (B) Increased serum uPAR levels in human MM and lung cancer patients groups, compared to the non-neoplastic control group (means ± SEM; *P < 0.05, **P < 0.01; m.s., not significant). (C) Summary scheme. uPAR-associated cellular signaling, and synergy of uPAR overexpression with reduced cisplatin sensitivity by activated AKT signalling in MM cells.