Figure 7. Development and stemness modules significantly enriched for ploidy-regulated genes from all three c-Myc interacting gene lists (for heart-liver, placenta and heart-liver-placenta).

Designations for X, Y, figures at the bottom of the bars, red and white arrows pointing to the tips of the bars, bars with no arrows and red diamonds are the same as for Figure 5. This chart indicates that polyploidy is linked with metabolism activation and modification. This chart demonstrates common nature of ploidy-related stemness and the induction of epithelial-to -mesenchymal transition. The stemness is seen from the upregulation of modules related to stem cell and signaling by PI3K, NOTCH, HIPPO, FGF, FOXO/FOXM WNT, TGF-beta, c-MYC, Hedgehog. Activated epithelial-to -mesenchymal transition is evident from the activated EMT module.