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. 2016 Sep 21;7(46):75328–75338. doi: 10.18632/oncotarget.12175

Figure 5. RG7112-induced suppression of HIF-1alpha during hypoxia and reduction of tumor vascularity.

Figure 5

A. Normoxic and hypoxic (under 1% O2) expression of MDM2, p53, and HIF-1alpha in RMG-I and OVISE cells treated with or without 5 μM RG7112. B. Immunohistochemical staining of CD31 to detect microvessels in RMG-I tumors from control and RG7112-treated mice. C. Microvessels per field was calculated in RMG-I tumors from control and RG7112-treated mice, and compared by t-test.