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Both soluble and NW-Fc-coated tumor cells activate innate immune cells such as NK cells, macrophages (MØ), and dendritic cells (DC) via different types of activating Fc-γ receptors: FcγR1 (CD64), FcγRIIa (CD32a), FcγRIIIa (CD16a). ADCC = antibody-dependent cellular cytotoxicity, ADCP = antibody-dependent cellular phagocytose.
