Table 2. Top differentially expressed miRNAs, as detected by RNA sequencing.

MiRNA	EdgeR			DeSeq
	log2ratioa	P value	FDR	log2ratio	P value	FDR
hsa-miR-451a	−1.41	7.19E-07	0.0004	−1.45	5.72E-05	0.0327
hsa-miR-107	−1.32	2.74E-06	0.0008	−1.36	1.26E-04	0.0361
hsa-miR-4732-5p	−1.69	5.27E-06	0.0010	−1.73	6.47E-04	0.0683
hsa-miR-3688-3p	−2.56	1.43E-05	0.0016	−2.64	8.73E-04	0.0683
hsa-miR-485-3p	1.63	1.43E-05	0.0016	1.60	4.11E-04	0.0681
hsa-miR-4306	−1.47	5.37E-05	0.0051	−1.51	8.98E-04	0.0683
hsa-miR-486-5p	−1.16	7.81E-05	0.0062	−1.20	4.77E-04	0.0681
hsa-miR-3143	−1.56	8.90E-05	0.0062	−1.62	1.88E-03	0.0975
hsa-miR-4433b-5p	1.57	9.72E-05	0.0062	1.55	9.56E-04	0.0683
hsa-miR-96-5p	−1.16	3.33E-04	0.0150	−1.20	1.34E-03	0.0784
hsa-miR-370-3p	1.29	3.42E-04	0.0150	1.25	1.37E-03	0.0784
hsa-miR-151b	−1.31	2.65E-04	0.0150
hsa-miR-451b	−5.68	3.24E-04	0.0150

Top down-regulated				Top up-regulated
MiRNA	log2ratio	P value	FDR	MiRNA	log2ratio	P value	FDR
hsa-miR-451b	−5.68	3.24E-04	0.0150	hsa-miR-370-3p	1.29	3.42E-04	0.0150
hsa-miR-4482-3p	−4.54	9.41E-04	0.0256	hsa-miR-758-3p	1.35	3.09E-03	0.0414
hsa-miR-548ac	−3.72	1.11E-03	0.0287	hsa-miR-136-5p	1.40	3.45E-03	0.0437
hsa-miR-3688-3p	−2.56	1.43E-05	0.0016	hsa-miR-429	1.42	3.14E-03	0.0414
hsa-miR-3200-5p	−2.21	7.30E-04	0.0236	hsa-miR-654-5p	1.46	7.91E-04	0.0236
hsa-miR-4732-5p	−1.69	5.27E-06	0.0010	hsa-miR-369-5p	1.47	2.72E-03	0.0409
hsa-miR-3143	−1.56	8.90E-05	0.0062	hsa-miR-4433b-5p	1.57	9.72E-05	0.0062
hsa-miR-4448	−1.52	2.27E-03	0.0403	hsa-miR-485-3p	1.63	1.43E-05	0.0016
hsa-miR-3143	−1.56	8.90E-05	0.0062	hsa-miR-337-3p	1.85	1.86E-03	0.0380

^aFold difference between the recurrent and non-recurrent groups. A negative value indicates under-expression, and a positive value indicates over-expression in the recurrent group.