Skip to main content
NCBI home page
Proceedings of the National Academy of Sciences of the United States of America logoLink to Proceedings of the National Academy of Sciences of the United States of America
. 1983 Oct;80(19):6071–6075. doi: 10.1073/pnas.80.19.6071

Familial cutaneous malignant melanoma: autosomal dominant trait possibly linked to the Rh locus.

M H Greene, L R Goldin, W H Clark Jr, E Lovrien, K H Kraemer, M A Tucker, D E Elder, M C Fraser, S Rowe
PMCID: PMC534362  PMID: 6577466

Abstract

Segregation and linkage analyses were undertaken in families with multiple cases of cutaneous malignant melanoma (CMM) and a recently-described melanoma precursor, the dysplastic nevus syndrome (DNS). Clinical and laboratory data, including 23 genetic markers, were collected on 401 members of 14 high-risk kindreds. Pedigree analysis was compatible with an autosomal dominant mode of inheritance for the familial CMM trait. Although a similar model probably applies to the DNS trait as well, segregation analysis could not confirm the presence of a major locus. However, linkage analysis suggested that an autosomal dominant model was appropriate for the DNS, and that a DNS/CMM susceptibility gene may be located on the short arm of chromosome 1, within 30 map units of the Rh locus [maximum logarithm of odds (lod) score = 2.00].

Full text

PDF
6071

Images in this article

6074Image
on p.6074

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Anderson D. E. Clinical characteristics of the genetic variety of cutaneous melanoma in man. Cancer. 1971 Sep;28(3):721–725. doi: 10.1002/1097-0142(197109)28:3<721::aid-cncr2820280330>3.0.co;2-1. [DOI] [PubMed] [Google Scholar]
  2. Anderson D. E., Smith J. L., Jr, McBride C. M. Hereditary aspects of malignant melanoma. JAMA. 1967 May 29;200(9):741–746. [PubMed] [Google Scholar]
  3. Bovet R., Bachmann B., Delacrétaz J. Le BK mole syndrome est-il toujours de transmission autosomique dominante? Ann Dermatol Venereol. 1980;107(12):1173–1178. [PubMed] [Google Scholar]
  4. Braun-Falco O., Landthaler M., Ryckmanns F. BK-Mole-Syndrom. Fortschr Med. 1979 Sep 20;97(35):1489–1494. [PubMed] [Google Scholar]
  5. CAWLEY E. P., KRUSE W. T., PINKUS H. K. Genetic aspects of malignant melanoma. AMA Arch Derm Syphilol. 1952 Apr;65(4):440–450. doi: 10.1001/archderm.1952.01530230064006. [DOI] [PubMed] [Google Scholar]
  6. Clark W. H., Jr, Reimer R. R., Greene M., Ainsworth A. M., Mastrangelo M. J. Origin of familial malignant melanomas from heritable melanocytic lesions. 'The B-K mole syndrome'. Arch Dermatol. 1978 May;114(5):732–738. [PubMed] [Google Scholar]
  7. Duggleby W. F., Stoll H., Priore R. L., Greenwald P., Graham S. A genetic analysis of melanoma--polygenic inheritance as a threshold trait. Am J Epidemiol. 1981 Jul;114(1):63–72. doi: 10.1093/oxfordjournals.aje.a113175. [DOI] [PubMed] [Google Scholar]
  8. Elder D. E., Goldman L. I., Goldman S. C., Greene M. H., Clark W. H., Jr Dysplastic nevus syndrome: a phenotypic association of sporadic cutaneous melanoma. Cancer. 1980 Oct 15;46(8):1787–1794. doi: 10.1002/1097-0142(19801015)46:8<1787::aid-cncr2820460816>3.0.co;2-s. [DOI] [PubMed] [Google Scholar]
  9. Elder D. E., Green M. H., Guerry D., 4th, Kraemer K. H., Clark W. H., Jr The dysplastic nevus syndrome: our definition. Am J Dermatopathol. 1982 Oct;4(5):455–460. doi: 10.1097/00000372-198210000-00014. [DOI] [PubMed] [Google Scholar]
  10. Elston R. C., Stewart J. A general model for the genetic analysis of pedigree data. Hum Hered. 1971;21(6):523–542. doi: 10.1159/000152448. [DOI] [PubMed] [Google Scholar]
  11. Greene M. H., Clark W. H., Jr, Tucker M. A., Elder D. E., Kraemer K. H., Fraser M. C., Bondi E. E., Guerry D., Tuthill R., Hamilton R. Precursor naevi in cutaneous malignant melanoma: a proposed nomenclature. Lancet. 1980 Nov 8;2(8202):1024–1024. doi: 10.1016/s0140-6736(80)92176-5. [DOI] [PubMed] [Google Scholar]
  12. Greene M. H., Reimer R. R., Clark W. H., Jr, Mastrangelo M. J. Precursor lesions in familial melanoma. Semin Oncol. 1978 Mar;5(1):85–87. [PubMed] [Google Scholar]
  13. Happle R., Traupe H., Vakilzadeh F., Macher E. Arguments in favor of a polygenic inheritance of precursor nevi. J Am Acad Dermatol. 1982 Apr;6(4 Pt 1):540–543. doi: 10.1016/s0190-9622(82)80369-1. [DOI] [PubMed] [Google Scholar]
  14. Hawkins B. R., Dawkins R. L., Hockey A., Houliston J. B., Kirk R. L. Evidence for linkage between HLA and malignant melanoma. Tissue Antigens. 1981 May;17(5):540–541. doi: 10.1111/j.1399-0039.1981.tb00742.x. [DOI] [PubMed] [Google Scholar]
  15. Hundeiker M., Ruppel R., Schmitt H. Familiäre maligne Melanome und atypische disseminierte Pigmentale (BK-Mole-Syndrom). Hautarzt. 1980 Jan;31(1):42–46. [PubMed] [Google Scholar]
  16. Lynch H. T., Frichot B. C., 3rd, Lynch J. F. Familial atypical multiple mole-melanoma syndrome. J Med Genet. 1978 Oct;15(5):352–356. doi: 10.1136/jmg.15.5.352. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. MORTON N. E. Sequential tests for the detection of linkage. Am J Hum Genet. 1955 Sep;7(3):277–318. [PMC free article] [PubMed] [Google Scholar]
  18. Merritt A. D., Rivas M. L., Bixler D., Newell R. Salivary and pancreatic amylase: electrophoretic characterizations and genetic studies. Am J Hum Genet. 1973 Sep;25(5):510–522. [PMC free article] [PubMed] [Google Scholar]
  19. Ott J. Estimation of the recombination fraction in human pedigrees: efficient computation of the likelihood for human linkage studies. Am J Hum Genet. 1974 Sep;26(5):588–597. [PMC free article] [PubMed] [Google Scholar]
  20. Rahbari H., Mehregan A. H. Sporadic atypical mole syndrome. A report of five nonfamilial B-K mole syndrome-like cases and histopathologic findings. Arch Dermatol. 1981 Jun;117(6):329–331. doi: 10.1001/archderm.117.6.329. [DOI] [PubMed] [Google Scholar]
  21. Reimer R. R., Clark W. H., Jr, Greene M. H., Ainsworth A. M., Fraumeni J. F., Jr Precursor lesions in familial melanoma. A new genetic preneoplastic syndrome. JAMA. 1978 Feb 20;239(8):744–746. [PubMed] [Google Scholar]
  22. Smith P. J., Greene M. H., Adams D., Paterson M. C. Abnormal responses to the carcinogen 4-nitroquinoline 1-oxide of cultured fibroblasts from patients with dysplastic nevus syndrome and hereditary cutaneous malignant melanoma. Carcinogenesis. 1983;4(7):911–916. doi: 10.1093/carcin/4.7.911. [DOI] [PubMed] [Google Scholar]
  23. Smith P. J., Greene M. H., Devlin D. A., McKeen E. A., Paterson M. C. Abnormal sensitivity to UV-radiation in cultured skin fibroblasts from patients with hereditary cutaneous malignant melanoma and dysplastic nevus syndrome. Int J Cancer. 1982 Jul 15;30(1):39–45. doi: 10.1002/ijc.2910300108. [DOI] [PubMed] [Google Scholar]
  24. Wallace D. C., Beardmore G. L., Exton L. A. Familial malignant melanoma. Ann Surg. 1973 Jan;177(1):15–20. doi: 10.1097/00000658-197301000-00004. [DOI] [PMC free article] [PubMed] [Google Scholar]
  25. Wallace D. C., Exton L. A., McLeod G. R. Genetic factor in malignant melanoma. Cancer. 1971 May;27(5):1262–1266. doi: 10.1002/1097-0142(197105)27:5<1262::aid-cncr2820270534>3.0.co;2-6. [DOI] [PubMed] [Google Scholar]
  26. Walter H., Brachtel R., Hilling M. On the incidence of blood group O and Gm(-1) phenotypes in patients with malignant melanoma. Hum Genet. 1979 May 23;49(1):71–81. doi: 10.1007/BF00277688. [DOI] [PubMed] [Google Scholar]

Articles from Proceedings of the National Academy of Sciences of the United States of America are provided here courtesy of National Academy of Sciences

RESOURCES