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. 2017 Mar 8;69(4):625–632. doi: 10.1161/HYPERTENSIONAHA.116.08507

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© 2017 The Authors.

Hypertension is published on behalf of the American Heart Association, Inc., by Wolters Kluwer Health, Inc. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution, and reproduction in any medium, provided that the original work is properly cited.

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Figure 2. — A, Ad-mCherry-hATP2Aa transfected stellate ganglia neurons from (4 to 5 wk, 90–120 g) Sprague–Dawley (SD) rat. (i) Bright field image, (ii) composite, and (iii) excitation at 587 nm to excite mCherry fluorescent tag. Only cells expressing mCherry fluorescence were used for experiments. B, Example raw data trace from isolated stellate ganglia neurons of the young SD rat (gray line, Ad-mCherry [empty]; black line, Ad-mCherry-hATP2Aa [SERCA (sarcoendoplasmic reticulum calcium ATPase)]) exposed to 50 mmol/L of KCl (30 s) to depolarize the neuron resulting in an increase in intracellular free Ca²⁺ ([Ca²⁺]_i). C, Group mean data showing peak depolarization-evoked intracellular free Ca²⁺ increase between Ad-mCherry (gray; n=57) and Ad-mCherry-hATP2Aa (black; n=68) transfected stellate neurons. D, Group mean data of 50% fall time of ([Ca²⁺]_i) from the peak (Ad-mCherry, gray; n=37; Ad-mCherry-hATP2Aa, black; n=42). *P<0.05.