Table 5. Multi-drug design for the prevention of HCC progression from stage I to stage II, based on the progression mechanism elucidated in Figure 6.

Drug molecule	Target gene
lestaurtinib	NTK2
dinaciclib	MYC
perifosine	AKT1
Multiple drug molecules

Lestaurtinib, dinaciclib, and perifosine were proposed to prevent HCC progression from stage I to stage II. The structures of these drug molecules (obtained from the ZINC database) are illustrated in the accompanying figure.