Table 5. The functional annotations enriched with genes interrupted by finasteride.
| Genes in the category | OR of enrichment | Adjusted P-value1 | |
|---|---|---|---|
| GO Terms | |||
| Intracellular steroid hormone receptor signaling pathway (GO:0030518) | EP300, PHB, SMARCA4, KAT5, UBE2I, SRC, CCNE1, PARK7, TRIM68, TADA3, CALR, PIAS1, NR0B1, RB1, UBE3A, NCOA6, CTNNB1, RNF4, GRIP1, MED24, RAN, MED1, FKBP4, NCOA2, SIRT1, SKP2, FHL2, BRCA1, CDK7, KDM3A, NCOA3, RNF6, NCOA4, DAXX, PMEPA1, PIAS2, HDAC1, AR, NCOA1, NR0B2, RNF14, FOXA1, TGFB1I1 | 24.73 | 1.24×10−47 |
| Androgen receptor signaling pathway (GO:0030521) | EP300, PHB, SMARCA4, KAT5, CCNE1, PARK7, TRIM68, PIAS1, RB1, UBE3A, CTNNB1, RNF4, MED24, GRIP1, RAN, MED1, FKBP4, NCOA2, SIRT1, FHL2, BRCA1, CDK7, KDM3A, NCOA3, RNF6, NCOA4, PMEPA1, DAXX, PIAS2, HDAC1, AR, NR0B2, NCOA1, RNF14, TGFB1I1 | 32.91 | 2.00×10−44 |
| KEGG Pathways | |||
| Steroid hormone biosynthesis (hsa00140) | AKR1D1, CYP3A7, CYP3A5, AKR1C1, SRD5A2, AKR1C3, SRD5A1, CYP3A4 | 23.88 | 7.16×10−9 |
| Oocyte meiosis (hsa04114) | AR, YWHAQ, PPP1CA, MAPK1, PRKACA, CCNE1, CALM1 | 10.45 | 1.43×10−5 |
| Progesterone-mediated oocyte maturation (hsa04914) | HSP90AA1, CDC25B, AKT1, MAPK1, PRKACA, RAF1 | 11.66 | 3.27×10−5 |
1
The p-values were calculated by hypergeometric test and adjusted with the Benjamini-Hochberg procedure.