Table 2. Diagnostic performance of five QMSPs on normal and cancer scrapings.
Gene | AUC (95% CI) | J | Cutoff | Positive normal | Positive cancer | P† | Positive ADC | Positive SCC | P‡ |
---|---|---|---|---|---|---|---|---|---|
SOX1 | 0.96 (0.93–0.99) | 0.885 | 19 | 1% | 90% | 10-37 | 88% | 91% | 0.528 |
SOX14 | 0.96 (0.93–0.99) | 0.883 | 70 | 4% | 92% | 10-36 | 88% | 95% | 0.118 |
TBX20 | 0.94 (0.90–0.97) | 0.802 | 140 | 6% | 86% | 10-29 | 82% | 89% | 0.266 |
SLC6A5 | 0.93 (0.89–0.96) | 0.789 | 315 | 2% | 81% | 10-28 | 82% | 80% | 0.760 |
GFRA1 | 0.92 (0.88–0.96) | 0.781 | 41 | 2% | 80% | 10-28 | 70% | 89% | 0.007 |
CI is the confidence interval
frequency normal vs. cancer
frequency ADC vs. SCC.