Table 2. Univariate and multivariate analyses of C5aR and other characteristics with OS and RFS.
| Characteristics | Univariate | Multivariate | ||
|---|---|---|---|---|
| HR (95% CI) | P | HR (95% CI) | P | |
| Overall Survival | ||||
| Age (> 55 yr vs ≤ 55 yr) | 2.012 (1.269–3.192) | 0.003 | 1.579 (0.993–2.512) | 0.054 |
| Gender (male vs female) | 1.039 (0.643–1.679) | 0.874 | ||
| Tumor size (> 4.0 cm vs ≤ 4.0 cm) | 2.137 (1.363–3.350) | 0.001 | 1.130 (0.700–1.825) | 0.617 |
| Fuhrman grade (categorical) | 2.268 (1.603–3.208) | < 0.001 | 2.026 (1.382–2.970) | < 0.001 |
| Necrosis (present vs absent) | 2.760 (1.673–4.553) | < 0.001 | 1.907 (1.121–3.243) | 0.017 |
| TNM stage (categorical) | 2.057 (1.685–2.510) | < 0.001 | 1.766 (1.420–2.196) | < 0.001 |
| ECOG-PS (≥ 1 vs 0) | 3.236 (2.080–5.036) | < 0.001 | 2.125 (1.329–3.398) | 0.002 |
| C5aR level (high vs low) | 1.996 (1.253–3.178) | 0.004 | 1.860 (1.163–2.977) | 0.010 |
| Recurrence-free Survival | ||||
| Age (> 55 yr vs ≤ 55 yr) | 1.627 (1.003–2.637) | 0.048 | 1.237 (0.758–2.019) | 0.395 |
| Gender (male vs female) | 0.937 (0.564–1.558) | 0.803 | ||
| Tumor size (> 4.0 cm vs ≤ 4.0 cm) | 2.455 (1.509–3.993) | < 0.001 | 1.491 (0.893–2.491) | 0.127 |
| Fuhrman grade (categorical) | 2.167 (1.485–3.163) | < 0.001 | 1.924 (1.263–2.931) | 0.002 |
| Necrosis (present vs absent) | 3.014 (1.771–5.128) | < 0.001 | 2.029 (1.144–3.598) | 0.016 |
| TNM stage (categorical) | 1.866 (1.484–2.397) | < 0.001 | 1.609 (1.240–2.088) | < 0.001 |
| ECOG-PS (≥ 1 vs 0) | 2.875 (1.778–4.647) | < 0.001 | 2.241 (1.361–3.689) | 0.002 |
| C5aR level (high vs low) | 2.316 (1.384–3.877) | 0.001 | 1.835 (1.091–3.087) | 0.002 |
Abbreviations: HR, Hazard Ratio; CI, confidence interval; ECOG-PS, Eastern Cooperative Oncology Group performance status.