Table 3. Multivariate analyses of C5a-C5aR and other characteristics with OS and RFS.
| Characteristics | Overall Survival | Recurrence-free Survival | ||
|---|---|---|---|---|
| HR (95% CI) | P | HR (95% CI) | P | |
| Age (> 55 yr vs ≤ 55 yr) | 1.569 (0.986–2.498) | 0.057 | 1.212 (0.743–1.978) | 0.440 |
| Tumor size (> 4.0 cm vs ≤ 4.0 cm) | 1.086 (0.670–1.760) | 0.738 | 1.462 (0.874–2.447) | 0.148 |
| Fuhrman grade (categorical) | 1.864 (1.263–2.750) | 0.002 | 1.849 (1.201–2.847) | 0.005 |
| Necrosis (present vs absent) | 1.740 (1.021–2.965) | 0.042 | 1.836 (1.034–3.259) | 0.038 |
| TNM stage (categorical) | 1.709 (1.378–2.121) | < 0.001 | 1.608 (1.239–2.085) | < 0.001 |
| ECOG-PS (≥ 1 vs 0) | 2.305 (1.434–3.703) | 0.001 | 2.447 (1.4794.048) | < 0.001 |
| C5a-C5aR (enriched vs non-enriched) | 2.118 (1.343–3.342) | 0.001 | 1.715 (1.039–2.830) | 0.035 |
Abbreviations: HR, Hazard Ratio; CI, confidence interval; ECOG-PS, Eastern Cooperative Oncology Group performance status.