Abstract
The data shows attentional function, impulsivity, motivation, motor function, and motor activity in rats treated with varenicline, a stop-smoking aid. The data also shows these parameters in rats treated with varenicline after acute/chronic nicotine administration. Our interpretation and discussion of these data were described in the article “Varenicline Provokes Impulsive Action by Stimulating α4β2 Nicotinic Acetylcholine Receptors in the Infralimbic Cortex in a Nicotine Exposure Status-Dependent Manner” (Ohmura et al., 2017) [1].
Specifications Table
| Subject area | Biology, Psychology |
| More specific subject area | Psychopharmacology |
| Type of data | Excel file |
| How data was acquired | Aluminum operant chambers measuring 26 cm×26 cm×26 cm (Med Associates Inc., St. Albans, VT, USA) were used. |
| Data format | Raw |
| Experimental factors | Nicotine and/or varenicline administration |
| Experimental features | Adult male Wistar/ST rats were used. |
| Data source location | N/A |
| Data accessibility | All data were presented here. |
Value of the data
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The effects of stop-smoking aids on cognitive functions were of interest to many people.
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Some researchers might be interested in some parameters we did not focus on in the research paper [1].
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Clinicians can design human studies based on the animal data.
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The raw data would be useful if one would like to conduct reanalysis or meta-analysis.
1. Data
Data file 1 contains the raw data regarding Fig. 1 in [1]: several parameters (see below, Section 2) in a 3-choice serial reaction time task (3-CSRTT) in nicotine-naïve rats. Data file 2 contains the raw data regarding Fig. 2 in [1]: several parameters in the 3-CSRTT in nicotine-naïve rats after varenicline administration followed by microinjection of a α4β2 nicotinic acetylcholine receptor antagonist into the infralimbic cortex (IL). Data file 3 contains the raw data regarding Fig. 3 in [1]: several parameters in the 3-CSRTT in nicotine-naïve rats after acute s.c. injection of nicotine and varenicline. Data file 4 contains the raw data regarding Figs. 4 and 5 in [1]: several parameters in the 3-CSRTT after continuous infusion of nicotine and acute/repeated oral administration of varenicline.
2. Experimental design, materials and methods
We used a 3-choice serial reaction time task to assess impulsivity and other cognitive functions in rats [1]. We recorded seven behavioral parameters, as described below.
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(a)
Premature responses (counts per session): a measure of impulsivity.
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(b)
Accuracy (percentage of correct responses): a measure of attentional function.
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(c)
Omissions (counts per session): a measure of attentional function and motivation.
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(d)
Perseverative responses (counts per session): a measure of compulsivity.
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(e)
Responses during time-out (counts per session): a measure of motivation and motor activity.
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(f)
Correct response latency(s): a measure of attentional function, motivation, motor function, and decision time.
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(g)
Reward latency (s): a measure of motivation and motor function.
As for data file 1, nicotine naïve rats received acute s.c. injection of varenicline (0, 0.0075, 0.075, and 0.75 mg/kg) 60 min before the testing session.
As for data file 2, nicotine naïve rats received acute s.c. injection of varenicline (0 and 0.075 mg/kg) 60 min before the testing session and intra-IL microinjection of dihydro-β-erythroidine (DHβE; 0 and 6 μg/side), a preferential α4β2 nAChR antagonist, 10 min before the testing session.
As for data file 3, nicotine naïve rats received acute s.c. injection of varenicline (0, 0.0075, 0.075, and 0.75 mg/kg, s.c.) 60 min before the testing session and acute s.c. injection of nicotine (0 and 0.2 mg/kg) 10 min before the testing session. The dose of nicotine was the same as that used in our previous studies, demonstrating that nicotine induced impulsive action [2], [3].
As for data file 4, rats received acute oral administration of varenicline (0.075 mg/kg) 60 min before the testing session after 8 days of continuous nicotine (9 mg/kg/day, salt) or sodium tartrate administration with osmotic minipumps. The blood concentrations resulting from this dose in rats are comparable to those measured in heavy smokers [4], [5]. Repeated oral administration of varenicline (0.075 mg/kg, once per day) was conducted after stopping continuous nicotine infusion.
Acknowledgements
This study was supported by a Grant from the Smoking Research Foundation (URL: http://www.srf.or.jp/english/index.html), Grant-in-Aid for Scientific Research on Innovative Areas 26118701, 26120701(Y.O.), and Grant-in-Aid for Young Scientists (A) 25713043 (Y.O.) from the Ministry of Education, Culture, Sports, Science and Technology of Japan. We would like to thank Hiromi Matsubara and Tomoko Furukawa for helping us train rats. We also thank Katsuhiro Aikawa for technical support of surgery.
Footnotes
Transparency data associated with this article can be found in the online version at doi:10.1016/j.dib.2017.02.050.
Supplementary data associated with this article can be found in the online version at doi:10.1016/j.dib.2017.02.050.
Transparency document. Supplementary material
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Appendix A. Supplementary material
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References
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Associated Data
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Supplementary Materials
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