Figure 3. Inhibitors of oxidative phosphorylation inhibit the development of osimertinib resistance in an AMPK-independent manner.

(A–D) Cells were plated at low density, treated with the indicated compounds and scored for resistance as described in the Materials and Methods. Abbreviations: osimertinib (Osi), phenformin (Phen), metformin (Met), buformin (Buf), BAY 87-2243 (BAY), oligomycin (Oligo).