Table 3. Stratified analyses for TINCR genotypes in cases and controls.
| Variable | n GA+AA (%)/n GG (%) for rs8113645 | Allelic odds ratios and 95% confidence intervals for rs8113645 | n AG+GG (%)/ n AA (%) for rs2288947 | Allelic odds ratios and 95% confidence intervals for rs2288947 | ||||
|---|---|---|---|---|---|---|---|---|
| Cases | Controls | Adjusted OR (95% Cl)* |
P value | Cases | Controls | Adjusted OR (95% Cl)* |
P value | |
| Age (y), median | ||||||||
| ≥ 60 | 72(12.0)/247(41.0) | 75(12.5)/206(34.2) | 0.77 (0.52-1.12) | 0.172 | 151(25.1)/168(27.9) | 152(25.2)/129(21.4) | 0.74 (0.53-1.03) | 0.075 |
| <60 | 58(9.60)/225(37.4) | 93(15.4)/228(37.9) | 0.63(0.43-0.92) | 0.016 | 128(21,3)/l 55(25.7) | 173(28.7)/148(24.6) | 0.69 (0.50-0.96) | 0.027 |
| Sex | ||||||||
| Females | 43(7.10)/121(20.1) | 46(7.6)/147(24.4) | 1.17(0.72-1.90) | 0.532 | 92(15.3)/72(12.0) | 91(15.1)/ 73(12.1) | 1.39(0.91-2.12) | 0.133 |
| Males | 87(14.5)/351(58.3) | 122(20.3)/287(47.7) | 0.58(0.42-0.80) | 0.001 | 187(31.1)/251(41.7) | 234(38.9)/204(33.9) | 0.57 (0.43-0.75) | 5.3*10−5 |
| Smoking Status | ||||||||
| Smokers | 26(4.3)/102(16.9) | 27(4.5)/67(11.1) | 0.63 (0.33-1.20) | 0.161 | 60(10.0)/68(11.3) | 64(10.6)/64(10.6) | 0.65 (0.38-1.13) | 0.129 |
| Nonsmokers | 104(17.3)/370(61.5) | 141(23.4)/367(61.0) | 0.73 (0.54-0.97) | 0.032 | 219(36.4)/255(42.4) | 261(43.4)/213(35.4) | 0.76 (0.59-0.98) | 0.035 |
| Residence | ||||||||
| Rural | 75(12.5)/283(47.0) | 94(15.6)/237(39.4) | 0.65(0.46-0.93) | 0.019 | 164(27.2)/194(32.2) | 192(31.9)/166(27.6) | 0.73 (0.54-0.99) | 0.042 |
| Urban | 55(9.1)/189(31.4) | 74(12.3)/197(32.7) | 0.78 (0.52-1.17) | 0.229 | 115(19.1)/129(21.4) | 133(22.1)/l 11(18.4) | 0.75 (0.53-1.07) | 0.111 |
* Adjusted for age, sex, smoking status, residence, hypertension, and diabetes.