Table 10. Gene-environment interaction.
Factors | β | S.E. | Wald χ2 | OR (95%CI) a | P |
---|---|---|---|---|---|
rs1047840 × Smoking | 0.428 | 0.093 | 21.020 | 1.534(1.278∼1.842) | 0.000 |
rs1047840 × Alcohol Consumption | 0.336 | 0.096 | 12.225 | 1.399(1.159∼1.689) | 0.000 |
rs1047840 × HBV Infection | 2.102 | 0.074 | 809.417 | 8.818(7.078∼9.456) | 0.000 |
rs1047840 × HCC family history | 0.229 | 0.235 | 0.949 | 1.257(0.793∼1.293) | 0.330 |
rs1776148 × Smoking | 0.424 | 0.093 | 20.652 | 1.527(1.272∼1.833) | 0.000 |
rs1776148 × Alcohol Consumption | 0.318 | 0.095 | 11.066 | 1.374(1.139∼1.657) | 0.001 |
rs1776148 × HBV Infection | 2.080 | 0.073 | 820.029 | 8.003(6.941∼9.288) | 0.000 |
rs1776148 × HCC family history | 0.236 | 0.223 | 1.022 | 1.266(0.801∼2.001) | 0.312 |
rs3754093 × Smoking | 0.421 | 0.103 | 16.756 | 1.524(1.245∼1.864) | 0.000 |
rs3754093 × Alcohol Consumption | 0.367 | 0.105 | 12.101 | 1.443(1.174∼1.775) | 0.001 |
rs3754093 × HBV Infection | 2.326 | 0.092 | 641.686 | 10.235(8.549∼12.253) | 0.000 |
rs3754093 × HCC family history | 0.186 | 0.269 | 0.477 | 1.204(0.711∼2.041) | 0.490 |
rs4149867 × Smoking | 0.462 | 0.124 | 13.852 | 1.587(1.244∼2.023) | 0.000 |
rs4149867 × Alcohol Consumption | 0.385 | 0.134 | 8.240 | 1.469(1.130∼1.910) | 0.004 |
rs4149867 × HBV Infection | 3.238 | 0.126 | 664.917 | 25.485(19.925∼32.597) | 0.000 |
rs4149867 × HCC family history | 0.391 | 0.340 | 1.324 | 1.478(0.760∼2.876) | 0.250 |
rs4149963 × Smoking | 0.610 | 0.149 | 16.769 | 1.840(1.374∼2.464) | 0.000 |
rs4149963 × Alcohol Consumption | 0.454 | 0.159 | 8.276 | 1.580(1.157∼2.158) | 0.004 |
rs4149963 × HBV Infection | 3.707 | 0.134 | 762.612 | 40.703(31.296∼52.965) | 0.000 |
rs4149963 × HCC family history | 0.350 | 0.401 | 0.760 | 1.419(0.646∼3.113) | 0.383 |
rs1776181 × Smoking | 0.497 | 0.110 | 20.283 | 1.644(1.324∼2.042) | 0.000 |
rs1776181 × Alcohol Consumption | 0.347 | 0.115 | 9.139 | 1.414(1.130∼1.771) | 0.003 |
rs1776181 × HBV Infection | 2.578 | 0.103 | 620.820 | 13.175(10.756∼16.137) | 0.000 |
rs1776181 × HCC family history | 0.372 | 0.316 | 1.384 | 1.450(0.781∼2.695) | 0.239 |
a: Adjusted by logistic regression for age, gender, nations, smoking, alcohol consumption, HBV infection, and HCC family history.