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. 2004 Dec 8;23(24):4878. doi: 10.1038/sj.emboj.7600518

A novel eukaryotic factor for cytosolic Fe–S cluster assembly

Amit Roy, Natalia Solodovnikova, Tracy Nicholson, William Antholine, William E Walden
PMCID: PMC535102

Abstract

Addendum to: The EMBO Journal (2003) 22, 4826–4835. doi:10.1093/emboj/cdg455


In the above article, the authors twice made the statement that Cfd1p was the first iron–sulfur cluster assembly factor to be found in the cytoplasm. Other recent publications have suggested that proteins that have been shown to function in Fe–S cluster assembly in mitochondria may exist at low levels in the cytoplasm (Land and Rouault, 1998; Tong and Rouault, 2000; Nakai et al, 2001). Since this article went to press, two additional papers have added to these findings (Tong et al, 2003; Nakai et al, 2004).

While some investigators have questioned whether Cfd1p is indeed the first reported cytosolic Fe–S cluster assembly factor, we emphasize that the significance of our finding is in identifying a new class of cluster assembly factor whose localization is exclusively cytoplasmic and whose function is demonstrably cytoplasmic as well.

References

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