Table 2. EGFR Exon 19 del and Exon 21 L858R Mutations Detected in Plasma cfDNA (ddPCR) Versus Paired Tumor Tissues (ARMS).
Plasma cfDNA | Tumor tissues | Total | Sensitivity | Specificity | Consistency rate | κ | P | |
---|---|---|---|---|---|---|---|---|
+ | − | |||||||
Exon19 del or Exon 21L858R |
||||||||
+ | 57 | 4 | 61 | 61.3% | 96.7% | 81.4% | 0.605 | <0.001 |
− | 36 | 118 | 154 | |||||
Total | 93 | 122 | 215 | |||||
Exon 19del | ||||||||
+ | 26 | 2 | 28 | 57.8% | 98.8% | 90.2% | 0.657 | <0.001 |
− | 19 | 168 | 187 | |||||
Total | 45 | 170 | 215 | |||||
Exon 21L858R | ||||||||
+ | 31 | 3 | 34 | 64.6% | 98.2% | 90.7% | 0.701 | <0.001 |
− | 17 | 164 | 181 | |||||
Total | 48 | 167 | 215 |